Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028842235> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2028842235 endingPage "116" @default.
- W2028842235 startingPage "111" @default.
- W2028842235 abstract "Abstract: Prior studies from this laboratory have established that angiotensinogen, the prohormone of angiotensin, is unevenly distributed in the rat brain and that adrenalectomy selectively perturbs levels of the prohormone in regions associated with cardiovascular neural pathways. However, plasma angiotensinogen levies are 102-103 times higher in plasma than in brain, so that the observation of a unique distribution of brain angiotensinogen may reflect variable plasma contamination. Studies were therefore undertaken to establish whether adrenalectomy selectively alters regional blood flow, blood volume, or plasma contamination of brain tissue, thereby artifactitiously altering apparent angiotensinogen levels. Radioactive 2-deoxyglucose, iodoantipyrine, and inulin were employed in these analyses. We conclude that variations in blood flow do not explain the selective effects of adrenalectomy, but that a variable extent of residual plasma contamination (remaining after transcardiac perfusion) is partially reflected in our earlier data. However, after correcting for plasma contamination, we still find significant changes in selected areas of the rat brain following adrenalectomy. Finally, our results demonstrate the necessity for direct quantitation of plasma contamination of brain tissue segments. This is shown to have relevance in other situations, such as corticosterone binding globulin contamination of brain corticosterone receptor binding." @default.
- W2028842235 created "2016-06-24" @default.
- W2028842235 creator A5007898097 @default.
- W2028842235 creator A5022454108 @default.
- W2028842235 creator A5072892481 @default.
- W2028842235 date "1982-07-01" @default.
- W2028842235 modified "2023-10-16" @default.
- W2028842235 title "Relationship Between Regional Brain Angiotensinogen a Local Blood Flow and Volume in the Adrenalectomize Rat: Application of Approach to Quantification of Brain Corticosterone Receptors" @default.
- W2028842235 cites W1963540665 @default.
- W2028842235 cites W1987150243 @default.
- W2028842235 cites W2002100511 @default.
- W2028842235 cites W2016194209 @default.
- W2028842235 cites W2022551744 @default.
- W2028842235 cites W2048155567 @default.
- W2028842235 cites W2090306035 @default.
- W2028842235 cites W2155014088 @default.
- W2028842235 cites W2310907465 @default.
- W2028842235 doi "https://doi.org/10.1111/j.1471-4159.1982.tb04708.x" @default.
- W2028842235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7086405" @default.
- W2028842235 hasPublicationYear "1982" @default.
- W2028842235 type Work @default.
- W2028842235 sameAs 2028842235 @default.
- W2028842235 citedByCount "6" @default.
- W2028842235 crossrefType "journal-article" @default.
- W2028842235 hasAuthorship W2028842235A5007898097 @default.
- W2028842235 hasAuthorship W2028842235A5022454108 @default.
- W2028842235 hasAuthorship W2028842235A5072892481 @default.
- W2028842235 hasConcept C126322002 @default.
- W2028842235 hasConcept C134018914 @default.
- W2028842235 hasConcept C157767197 @default.
- W2028842235 hasConcept C170493617 @default.
- W2028842235 hasConcept C185592680 @default.
- W2028842235 hasConcept C2780087391 @default.
- W2028842235 hasConcept C2780352252 @default.
- W2028842235 hasConcept C71315377 @default.
- W2028842235 hasConcept C71924100 @default.
- W2028842235 hasConcept C86803240 @default.
- W2028842235 hasConceptScore W2028842235C126322002 @default.
- W2028842235 hasConceptScore W2028842235C134018914 @default.
- W2028842235 hasConceptScore W2028842235C157767197 @default.
- W2028842235 hasConceptScore W2028842235C170493617 @default.
- W2028842235 hasConceptScore W2028842235C185592680 @default.
- W2028842235 hasConceptScore W2028842235C2780087391 @default.
- W2028842235 hasConceptScore W2028842235C2780352252 @default.
- W2028842235 hasConceptScore W2028842235C71315377 @default.
- W2028842235 hasConceptScore W2028842235C71924100 @default.
- W2028842235 hasConceptScore W2028842235C86803240 @default.
- W2028842235 hasIssue "1" @default.
- W2028842235 hasLocation W20288422351 @default.
- W2028842235 hasLocation W20288422352 @default.
- W2028842235 hasOpenAccess W2028842235 @default.
- W2028842235 hasPrimaryLocation W20288422351 @default.
- W2028842235 hasRelatedWork W1979599944 @default.
- W2028842235 hasRelatedWork W1998694012 @default.
- W2028842235 hasRelatedWork W2015328630 @default.
- W2028842235 hasRelatedWork W2040902964 @default.
- W2028842235 hasRelatedWork W2053001742 @default.
- W2028842235 hasRelatedWork W2061766728 @default.
- W2028842235 hasRelatedWork W2070611918 @default.
- W2028842235 hasRelatedWork W2171404466 @default.
- W2028842235 hasRelatedWork W2265575926 @default.
- W2028842235 hasRelatedWork W2414846389 @default.
- W2028842235 hasVolume "39" @default.
- W2028842235 isParatext "false" @default.
- W2028842235 isRetracted "false" @default.
- W2028842235 magId "2028842235" @default.
- W2028842235 workType "article" @default.