FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028844570> ?p ?o ?g. }

• W2028844570 abstract "The end product of the breakdown of the heme group of hemoglobin and other heme-containing proteins is bilirubin. Bilirubin is hydrophobic and cannot be excreted as such. Therefore, mammals have a liver enzyme bilirubin UDP-glucuronosyltransferase (B-UGT), which conjugates bilirubin with glucuronic acid, thereby making the molecule much more water soluble. Bilirubin glucuronides are secreted into bile. Patients with Crigler-Najjar (CN) disease have a deficiency in bilirubin UDP-glucuronosyltransferase and accumulate high serum levels of bilirubin. An animal model for CN disease is the Gunn rat. The obvious target for gene therapy for CN disease is the liver, but because liver cells do only divide infrequently, they are difficult to transduce. To investigate whether cells that are easily transduced can be used to develop gene therapy for CN disease, we have transduced Gunn rat fibroblasts with B-UGT, using a recombinant retrovirus. Gunn rat fibroblasts expressing B-UGT were able to glucuronidate bilirubin present in cell culture media. In this study, we describe the intraperitoneal transplantation of Gunn rats with Gunn rat fibroblasts expressing B-UGT. Transplantation of the fibroblasts corrected the genetic deficiency of the Gunn rats, serum bilirubin concentrations of the transplanted Gunn rats were reduced to normal, and bilirubin glucuronides appeared in bile. However, due to the prolonged period of cell culture, the transplanted fibroblasts were transformed, and the experimental animals developed tumors after transplantation." @default.
• W2028844570 created "2016-06-24" @default.
• W2028844570 creator A5014158331 @default.
• W2028844570 creator A5026410723 @default.
• W2028844570 creator A5041017548 @default.
• W2028844570 creator A5044314042 @default.
• W2028844570 creator A5046543120 @default.
• W2028844570 creator A5056720047 @default.
• W2028844570 creator A5073250829 @default.
• W2028844570 creator A5011661329 @default.
• W2028844570 date "1997-01-01" @default.
• W2028844570 modified "2023-10-17" @default.
• W2028844570 title "Transplantation of Gunn Rats with Autologous Fibroblasts Expressing Bilirubin UDP-Glucuronosyltransferase: Correction of Genetic Deficiency and Tumor Formation" @default.
• W2028844570 cites W1481787056 @default.
• W2028844570 cites W1505781224 @default.
• W2028844570 cites W1572023751 @default.
• W2028844570 cites W1775799483 @default.
• W2028844570 cites W1790928245 @default.
• W2028844570 cites W1950804083 @default.
• W2028844570 cites W1968213269 @default.
• W2028844570 cites W1968960126 @default.
• W2028844570 cites W1991148746 @default.
• W2028844570 cites W2010413800 @default.
• W2028844570 cites W2021432236 @default.
• W2028844570 cites W2022190511 @default.
• W2028844570 cites W2032564106 @default.
• W2028844570 cites W2032985510 @default.
• W2028844570 cites W2036443821 @default.
• W2028844570 cites W2039908187 @default.
• W2028844570 cites W2043300139 @default.
• W2028844570 cites W2056515335 @default.
• W2028844570 cites W2062723580 @default.
• W2028844570 cites W2081705804 @default.
• W2028844570 cites W2091987058 @default.
• W2028844570 cites W2114689164 @default.
• W2028844570 cites W2120825516 @default.
• W2028844570 cites W2142638152 @default.
• W2028844570 cites W2395271082 @default.
• W2028844570 cites W2417690457 @default.
• W2028844570 cites W49145843 @default.
• W2028844570 doi "https://doi.org/10.1089/hum.1997.8.1-27" @default.
• W2028844570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8989992" @default.
• W2028844570 hasPublicationYear "1997" @default.
• W2028844570 type Work @default.
• W2028844570 sameAs 2028844570 @default.
• W2028844570 citedByCount "26" @default.
• W2028844570 countsByYear W20288445702012 @default.
• W2028844570 countsByYear W20288445702014 @default.
• W2028844570 countsByYear W20288445702015 @default.
• W2028844570 countsByYear W20288445702021 @default.
• W2028844570 crossrefType "journal-article" @default.
• W2028844570 hasAuthorship W2028844570A5011661329 @default.
• W2028844570 hasAuthorship W2028844570A5014158331 @default.
• W2028844570 hasAuthorship W2028844570A5026410723 @default.
• W2028844570 hasAuthorship W2028844570A5041017548 @default.
• W2028844570 hasAuthorship W2028844570A5044314042 @default.
• W2028844570 hasAuthorship W2028844570A5046543120 @default.
• W2028844570 hasAuthorship W2028844570A5056720047 @default.
• W2028844570 hasAuthorship W2028844570A5073250829 @default.
• W2028844570 hasConcept C100817775 @default.
• W2028844570 hasConcept C126322002 @default.
• W2028844570 hasConcept C134018914 @default.
• W2028844570 hasConcept C181199279 @default.
• W2028844570 hasConcept C185592680 @default.
• W2028844570 hasConcept C2776217839 @default.
• W2028844570 hasConcept C2776648616 @default.
• W2028844570 hasConcept C2777513400 @default.
• W2028844570 hasConcept C2779907587 @default.
• W2028844570 hasConcept C2781278898 @default.
• W2028844570 hasConcept C2911091166 @default.
• W2028844570 hasConcept C2911188197 @default.
• W2028844570 hasConcept C55493867 @default.
• W2028844570 hasConcept C71924100 @default.
• W2028844570 hasConcept C86803240 @default.
• W2028844570 hasConcept C87644729 @default.
• W2028844570 hasConceptScore W2028844570C100817775 @default.
• W2028844570 hasConceptScore W2028844570C126322002 @default.
• W2028844570 hasConceptScore W2028844570C134018914 @default.
• W2028844570 hasConceptScore W2028844570C181199279 @default.
• W2028844570 hasConceptScore W2028844570C185592680 @default.
• W2028844570 hasConceptScore W2028844570C2776217839 @default.
• W2028844570 hasConceptScore W2028844570C2776648616 @default.
• W2028844570 hasConceptScore W2028844570C2777513400 @default.
• W2028844570 hasConceptScore W2028844570C2779907587 @default.
• W2028844570 hasConceptScore W2028844570C2781278898 @default.
• W2028844570 hasConceptScore W2028844570C2911091166 @default.
• W2028844570 hasConceptScore W2028844570C2911188197 @default.
• W2028844570 hasConceptScore W2028844570C55493867 @default.
• W2028844570 hasConceptScore W2028844570C71924100 @default.
• W2028844570 hasConceptScore W2028844570C86803240 @default.
• W2028844570 hasConceptScore W2028844570C87644729 @default.
• W2028844570 hasLocation W20288445701 @default.
• W2028844570 hasLocation W20288445702 @default.
• W2028844570 hasOpenAccess W2028844570 @default.
• W2028844570 hasPrimaryLocation W20288445701 @default.
• W2028844570 hasRelatedWork W1489070406 @default.
• W2028844570 hasRelatedWork W1775799483 @default.
• W2028844570 hasRelatedWork W1878493196 @default.
• W2028844570 hasRelatedWork W1987113532 @default.
• W2028844570 hasRelatedWork W2008530488 @default.

• next