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• W2028850007 endingPage "397" @default.
• W2028850007 startingPage "387" @default.
• W2028850007 abstract "Antipsychotic treatment during pregnancy is indicated when risk of drug exposure to the fetus is outweighed by the untreated psychosis in the mother. Although increased risk of congenital malformation has not been associated with most available antipsychotic drugs, there is a paucity of knowledge on the subtle neurodevelopmental and behavioral consequences of prenatal receptor blockade by these drugs. In the present study, antipsychotic drugs, sulpiride (SUL, a selective D2 receptor antagonist) and risperidone (RIS, a D2/5HT2 receptor antagonist) were administered to pregnant Sprague-Dawley dams from gestational day 6 to 18. Both RIS and SUL prenatal exposed rats had lower birth body weights compared to controls. RIS exposure had a significant main effect to retard body weight growth in male offspring until postnatal day (PND) 60. Importantly, water maze tests revealed that SUL prenatal exposure impaired visual cue response in visual task performance (stimulus-response, S-R memory), but not place response as reflected in hidden platform task (spatial memory acquisition and retention). In addition, prenatal SUL treatment reduced spontaneous activity as measured in open field. Both behavioral deficits suggest that SUL prenatal exposure may lead to subtle disruption of striatum development and related learning and motor systems. RIS exposure failed to elicit deficits in both water maze tasks and increased rearing in open field test. These results suggest prenatal exposure to SUL and RIS may produce lasting effects on growth, locomotion and memory in rat offspring. And the differences may exist in the effects of antipsychotic drugs which selectively block dopamine D2 receptors (SUL) as compared to second generation drugs (RIS) that potently antagonize serotonin and dopamine receptors." @default.
• W2028850007 created "2016-06-24" @default.
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• W2028850007 date "2008-02-01" @default.
• W2028850007 modified "2023-10-14" @default.
• W2028850007 title "Distinct neurobehavioral consequences of prenatal exposure to sulpiride (SUL) and risperidone (RIS) in rats" @default.
• W2028850007 cites W118396326 @default.
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• W2028850007 cites W1584481186 @default.
• W2028850007 cites W184480178 @default.
• W2028850007 cites W1964176367 @default.
• W2028850007 cites W1964879653 @default.
• W2028850007 cites W1966439856 @default.
• W2028850007 cites W1967061503 @default.
• W2028850007 cites W1967688863 @default.
• W2028850007 cites W1973529564 @default.
• W2028850007 cites W1979855837 @default.
• W2028850007 cites W1985674713 @default.
• W2028850007 cites W1992822500 @default.
• W2028850007 cites W1996620939 @default.
• W2028850007 cites W2001567401 @default.
• W2028850007 cites W2003119385 @default.
• W2028850007 cites W2003909245 @default.
• W2028850007 cites W2005925690 @default.
• W2028850007 cites W2009052798 @default.
• W2028850007 cites W2012440492 @default.
• W2028850007 cites W2015005952 @default.
• W2028850007 cites W2015086858 @default.
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• W2028850007 cites W2021092383 @default.
• W2028850007 cites W2021482497 @default.
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• W2028850007 cites W2025755857 @default.
• W2028850007 cites W2030356863 @default.
• W2028850007 cites W2031994595 @default.
• W2028850007 cites W2034866415 @default.
• W2028850007 cites W2038370141 @default.
• W2028850007 cites W2040334756 @default.
• W2028850007 cites W2043326913 @default.
• W2028850007 cites W2046158894 @default.
• W2028850007 cites W2046598870 @default.
• W2028850007 cites W2052302319 @default.
• W2028850007 cites W2058610004 @default.
• W2028850007 cites W2059602719 @default.
• W2028850007 cites W2060571381 @default.
• W2028850007 cites W2060588252 @default.
• W2028850007 cites W2065318828 @default.
• W2028850007 cites W2067135083 @default.
• W2028850007 cites W2067506190 @default.
• W2028850007 cites W2074286781 @default.
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• W2028850007 cites W2085054347 @default.
• W2028850007 cites W2088033114 @default.
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• W2028850007 cites W2098467445 @default.
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• W2028850007 cites W2116821483 @default.
• W2028850007 cites W2118774378 @default.
• W2028850007 cites W2125367567 @default.
• W2028850007 cites W2136962131 @default.
• W2028850007 cites W2140221411 @default.
• W2028850007 cites W2164235884 @default.
• W2028850007 cites W2165216870 @default.
• W2028850007 cites W2167136925 @default.
• W2028850007 cites W2328192696 @default.
• W2028850007 cites W2436957139 @default.
• W2028850007 cites W4231020163 @default.
• W2028850007 cites W4235656987 @default.
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• W2028850007 cites W4251732014 @default.
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• W2028850007 doi "https://doi.org/10.1016/j.pnpbp.2007.09.005" @default.
• W2028850007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17935847" @default.
• W2028850007 hasPublicationYear "2008" @default.
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