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- W2028850807 abstract "Interferons (IFN) exert their multiple biological effects through the induction of expression of over 30 genes encoding proteins with antiviral, antiproliferative and immunomodulatory functions. Among the many IFN-inducible proteins are the Interferon Regulatory Factors (IRFs), a family of transcription regulators, originally consisting of the well-characterized IRF-1 and IRF-2 proteins; the family has now expanded to over 10 members and is still growing. The present review provides a detailed description of recently characterized IRF family members. Studies analyzing IRF-expressing cell lines and IRF knockout mice reveal that each member of the IRF family exerts distinct roles in biological processes such as pathogen response, cytokine signalling, cell growth regulation and hematopoietic development. Understanding the molecular mechanisms by which the IRFs affect these important cellular events and IFN expression will contribute to a greater understanding of events leading to various viral, immune and malignant disease states and will suggest novel strategies for antiviral and immune modulatory therapy." @default.
- W2028850807 created "2016-06-24" @default.
- W2028850807 creator A5036379648 @default.
- W2028850807 creator A5039478606 @default.
- W2028850807 creator A5042737704 @default.
- W2028850807 date "1997-12-01" @default.
- W2028850807 modified "2023-10-17" @default.
- W2028850807 title "The growing family of interferon regulatory factors" @default.
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- W2028850807 doi "https://doi.org/10.1016/s1359-6101(97)00019-1" @default.
- W2028850807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9620643" @default.
- W2028850807 hasPublicationYear "1997" @default.
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