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• W2028852083 endingPage "11532" @default.
• W2028852083 startingPage "11526" @default.
• W2028852083 abstract "Hypercholesterolemia is one of the major risk factors for the development of cardiovascular disease. This study aims to elucidate the effect of gossypin on cholesterol metabolism in HepG2 cells. Results indicated that gossypin significantly reduced the total cholesterol concentration in a dose-dependent manner. There was a time- and dose-dependent increase in the expression of low-density lipoprotein receptor (LDLR) protein. However, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol synthesis, was not affected by gossypin. Moreover, gossypin had no effect on nuclear sterol regulatory element binding proteins (SREBP)-2 abundance. The activity of gossypin on LDLR expression was inhibited by the extracellular signal-regulated kinase (ERK) inhibitor PD98059. Western blotting analysis revealed that gossypin treatment dose- and time-dependently increased ERK activation and preceded the up-regulation of LDLR expression. Collectively, these new findings identify gossypin as a new hypocholesterolemic agent that up-regulates LDLR expression independent of SREBP-2 but is dependent on ERK activation." @default.
• W2028852083 created "2016-06-24" @default.
• W2028852083 creator A5020086934 @default.
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• W2028852083 date "2008-11-14" @default.
• W2028852083 modified "2023-10-06" @default.
• W2028852083 title "Gossypin Up-Regulates LDL Receptor through Activation of ERK Pathway: A Signaling Mechanism for the Hypocholesterolemic Effect" @default.
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• W2028852083 doi "https://doi.org/10.1021/jf802607x" @default.
• W2028852083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19007237" @default.
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