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- W2028853845 abstract "Two requirements for the polyriboinosinate and polycytidylate complex (rIn·rCn) to induce human interferon in cell cultures are generally assumed: (1) intactness of the double-stranded complex (with a Tm higher than the incubation temperature); (2) adequate resistance to nucleases. In this study, the rIn or rCn strand in the complex was interrupted either by unpaired bases (U or G) or by bond breakage. These imperfect complexes have Tm values substantially higher than 37 °C and can be protected from nucleases by complex formation with polylysine; this complex formation does not impair the induction ability of rIn·rCn. The r(I39,U)n·rCn and r(I21,U)n·rCn complexes were found to have little induction ability, while rIn·r(C20,G)n, rIn·r(C22,U)n, rIn·(C13,U)n and rIn·r(C7,U)n were found to be active. Similarly, rIn·oligocytidylate complexes (e.g. rIn·(Cp)23G > p) were active, while oligoinosinate rCn complexes (e.g. rI19·rCn) generally were not. Addition of poly l- (or d-) lysine to these imperfect complexes, although rendering them resistant to enzymic destruction, did not increase their antiviral activity. Thus, for interferon induction, the structural requirements in strand continuity and base-pairing are apparently more stringent in the rIn strand than in the rCn strand. Two inducers, rIn·r(C13,U)n and rIn·r(C20,G)n, may have a better therapeutic index than rIn·rCn itself; they are hydrolyzed by nucleases five- to eight-fold faster, and yet are nearly as active as interferon inducers." @default.
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- W2028853845 date "1972-10-01" @default.
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- W2028853845 title "Structural requirements of the rIn·rCn complex for Induction of human interferon" @default.
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- W2028853845 doi "https://doi.org/10.1016/0022-2836(72)90560-8" @default.
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