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- W2028872952 abstract "T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with β-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has been established that the β-catenin-dependent gene expression is often downstream of the canonical Wnt signaling pathway. We have genetically manipulated the β-catenin gene and generated mutant mice that have shown an essential role for β-catenin and TCF1 during pre-T cell receptor (TCR) and TCR-dependent stages of T cell development. We have also demonstrated a function for TCF1 and β-catenin downstream of TCR signaling in the differentiation of mature CD4 T cells into T helper lineages." @default.
- W2028872952 created "2016-06-24" @default.
- W2028872952 creator A5000208362 @default.
- W2028872952 creator A5051546133 @default.
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- W2028872952 date "2010-01-16" @default.
- W2028872952 modified "2023-09-27" @default.
- W2028872952 title "TCF1 and β-catenin regulate T cell development and function" @default.
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- W2028872952 doi "https://doi.org/10.1007/s12026-009-8137-2" @default.
- W2028872952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2891409" @default.
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