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- W2028873212 abstract "Purpose To assess macular morphology in patients with multiple sclerosis (MS) with and without history of optic neuritis (ON).Methods Twenty-six MS patients were recruited in this study, and 26 randomly eyes were selected from 26 age-matched healthy subjects as controls. Optical coherence tomography (OCT) examination was performed on each eye using a Stratus OCT device. The raw OCT data were exported from the device and further processed using a custom-built algorithm (OCTRIMA). Thickness measurements of 7 intraretinal layers and the total retina were obtained. Eyes from MS patients were divided into 2 groups for statistical analyses. The ON+ group contained 26 eyes which had ON at least 6 months prior to enrollment. Twenty-three eyes had no history of ON (ON- group). All thickness measurements were compared among the 3 groups using ANOVA with Newman-Keuls post-hoc analysis.Results Significant decrease in thickness was observed in ON+ and ON- eyes compared to controls for the macula (290±6µm, 283±12µm and 267±12µm in the control, ON- and ON+ group, respectively), retinal nerve fiber layer (38±2µm, 35±2µm and 31±4µm, respectively) and ganglion cell layer and inner plexiform layer complex (71±4µm, 64±7µm and 53±7µm, respectively). No statistically significant difference in thickness was found for the remaining intraretinal layers between the 3 groups analyzed.Conclusion Atrophy of the ganglion cells and nerve fibers in the macula of MS patients was observed even without previous history of ON. Therefore, thickness measurements of ganglion cells might be useful in the diagnosis and follow-up of MS patients." @default.
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- W2028873212 date "2010-09-01" @default.
- W2028873212 modified "2023-09-26" @default.
- W2028873212 title "Evaluation of macular morphology in patients with multiple sclerosis" @default.
- W2028873212 doi "https://doi.org/10.1111/j.1755-3768.2010.440.x" @default.
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