FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028874480> ?p ?o ?g. }

• W2028874480 endingPage "22149" @default.
• W2028874480 startingPage "22141" @default.
• W2028874480 abstract "The ends of linear chromosomes are extended by telomerase, a ribonucleoprotein complex minimally consisting of a protein subunit called telomerase reverse transcriptase (TERT) and the telomerase RNA (TER). TERT functions by reverse transcribing a short template region of TER into telomeric DNA. Proper assembly of TERT and TER is essential for telomerase activity; however, a detailed understanding of how TERT interacts with TER is lacking. Previous studies have identified an RNA binding domain (RBD) within TERT, which includes three evolutionarily conserved sequence motifs: CP2, CP, and T. Here, we used site-directed hydroxyl radical probing to directly identify sites of interaction between the TERT RBD and TER, revealing that the CP2 motif is in close proximity to a conserved region of TER known as the template boundary element (TBE). Gel shift assays on CP2 mutants confirmed that the CP2 motif is an RNA binding determinant. Our results explain previous work that established that mutations to the CP2 motif of TERT and to the TBE of TER both permit misincorporation of nucleotides into the growing DNA strand beyond the canonical template. Taken together, these results suggest a model in which the CP2 motif binds the TBE to strictly define which TER nucleotides can be reverse transcribed." @default.
• W2028874480 created "2016-06-24" @default.
• W2028874480 creator A5001747434 @default.
• W2028874480 creator A5039931180 @default.
• W2028874480 creator A5054995381 @default.
• W2028874480 date "2013-07-01" @default.
• W2028874480 modified "2023-10-18" @default.
• W2028874480 title "A Conserved Motif in Tetrahymena thermophila Telomerase Reverse Transcriptase Is Proximal to the RNA Template and Is Essential for Boundary Definition" @default.
• W2028874480 cites W1604861940 @default.
• W2028874480 cites W1985623818 @default.
• W2028874480 cites W1991545568 @default.
• W2028874480 cites W2000571874 @default.
• W2028874480 cites W2000971601 @default.
• W2028874480 cites W2004748235 @default.
• W2028874480 cites W2009357812 @default.
• W2028874480 cites W2011251205 @default.
• W2028874480 cites W2024550280 @default.
• W2028874480 cites W2024951321 @default.
• W2028874480 cites W2032428352 @default.
• W2028874480 cites W2045702252 @default.
• W2028874480 cites W2052351457 @default.
• W2028874480 cites W2059665929 @default.
• W2028874480 cites W2063963182 @default.
• W2028874480 cites W2080776393 @default.
• W2028874480 cites W2080776447 @default.
• W2028874480 cites W2083968461 @default.
• W2028874480 cites W2101014559 @default.
• W2028874480 cites W2103694365 @default.
• W2028874480 cites W2106792251 @default.
• W2028874480 cites W2117969511 @default.
• W2028874480 cites W2126535236 @default.
• W2028874480 cites W2144215662 @default.
• W2028874480 cites W2150490516 @default.
• W2028874480 cites W2154503882 @default.
• W2028874480 cites W2157638309 @default.
• W2028874480 cites W2163231075 @default.
• W2028874480 cites W2165961683 @default.
• W2028874480 cites W2168419371 @default.
• W2028874480 doi "https://doi.org/10.1074/jbc.m113.452425" @default.
• W2028874480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3724666" @default.
• W2028874480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23760279" @default.
• W2028874480 hasPublicationYear "2013" @default.
• W2028874480 type Work @default.
• W2028874480 sameAs 2028874480 @default.
• W2028874480 citedByCount "13" @default.
• W2028874480 countsByYear W20288744802013 @default.
• W2028874480 countsByYear W20288744802015 @default.
• W2028874480 countsByYear W20288744802016 @default.
• W2028874480 countsByYear W20288744802017 @default.
• W2028874480 countsByYear W20288744802018 @default.
• W2028874480 countsByYear W20288744802020 @default.
• W2028874480 countsByYear W20288744802021 @default.
• W2028874480 countsByYear W20288744802022 @default.
• W2028874480 crossrefType "journal-article" @default.
• W2028874480 hasAuthorship W2028874480A5001747434 @default.
• W2028874480 hasAuthorship W2028874480A5039931180 @default.
• W2028874480 hasAuthorship W2028874480A5054995381 @default.
• W2028874480 hasBestOaLocation W20288744801 @default.
• W2028874480 hasConcept C104292427 @default.
• W2028874480 hasConcept C104317684 @default.
• W2028874480 hasConcept C125593758 @default.
• W2028874480 hasConcept C132677234 @default.
• W2028874480 hasConcept C153911025 @default.
• W2028874480 hasConcept C156719811 @default.
• W2028874480 hasConcept C177336024 @default.
• W2028874480 hasConcept C199216141 @default.
• W2028874480 hasConcept C2777166614 @default.
• W2028874480 hasConcept C3017666073 @default.
• W2028874480 hasConcept C34558173 @default.
• W2028874480 hasConcept C54355233 @default.
• W2028874480 hasConcept C552990157 @default.
• W2028874480 hasConcept C55493867 @default.
• W2028874480 hasConcept C67705224 @default.
• W2028874480 hasConcept C75934600 @default.
• W2028874480 hasConcept C86803240 @default.
• W2028874480 hasConcept C94581717 @default.
• W2028874480 hasConcept C95444343 @default.
• W2028874480 hasConceptScore W2028874480C104292427 @default.
• W2028874480 hasConceptScore W2028874480C104317684 @default.
• W2028874480 hasConceptScore W2028874480C125593758 @default.
• W2028874480 hasConceptScore W2028874480C132677234 @default.
• W2028874480 hasConceptScore W2028874480C153911025 @default.
• W2028874480 hasConceptScore W2028874480C156719811 @default.
• W2028874480 hasConceptScore W2028874480C177336024 @default.
• W2028874480 hasConceptScore W2028874480C199216141 @default.
• W2028874480 hasConceptScore W2028874480C2777166614 @default.
• W2028874480 hasConceptScore W2028874480C3017666073 @default.
• W2028874480 hasConceptScore W2028874480C34558173 @default.
• W2028874480 hasConceptScore W2028874480C54355233 @default.
• W2028874480 hasConceptScore W2028874480C552990157 @default.
• W2028874480 hasConceptScore W2028874480C55493867 @default.
• W2028874480 hasConceptScore W2028874480C67705224 @default.
• W2028874480 hasConceptScore W2028874480C75934600 @default.
• W2028874480 hasConceptScore W2028874480C86803240 @default.
• W2028874480 hasConceptScore W2028874480C94581717 @default.
• W2028874480 hasConceptScore W2028874480C95444343 @default.
• W2028874480 hasIssue "30" @default.
• W2028874480 hasLocation W20288744801 @default.

• next