Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028874719> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2028874719 abstract "Peptidyl methylcoumarin amides are well established as model substrates for understanding protease specificity, but the corresponding methylcoumarin esters have attracted scant attention despite their potential utility in active-site titration and mechanistic characterization. We have devised techniques for the synthesis and deprotection of extended peptidyl methylcoumarin esters in good to moderate yields, and we have demonstrated their suitability for steady-state characterization and active-site titration of the Saccharomyces cerevisiae processing protease Kex2. Additionally, we have used one of these compounds to active-site titrate the homologous enzyme PC2, which had not previously been feasible using other types of substrates. These compounds should thus prove widely suitable for use as substrates and active-site titrants not only for proteases of the prohormone processing family but also for a wide range of other serine proteases." @default.
- W2028874719 created "2016-06-24" @default.
- W2028874719 creator A5067347941 @default.
- W2028874719 creator A5076058258 @default.
- W2028874719 creator A5087101413 @default.
- W2028874719 date "2000-05-01" @default.
- W2028874719 modified "2023-09-27" @default.
- W2028874719 title "Synthesis of Peptidyl Methylcoumarin Esters as Substrates and Active-Site Titrants for the Prohormone Processing Proteases Kex2 and PC2" @default.
- W2028874719 cites W1166688871 @default.
- W2028874719 cites W1488573465 @default.
- W2028874719 cites W1498441627 @default.
- W2028874719 cites W1524328823 @default.
- W2028874719 cites W1967948218 @default.
- W2028874719 cites W1971022925 @default.
- W2028874719 cites W1982612227 @default.
- W2028874719 cites W1987057684 @default.
- W2028874719 cites W1990623885 @default.
- W2028874719 cites W1991104246 @default.
- W2028874719 cites W1992643657 @default.
- W2028874719 cites W2000337400 @default.
- W2028874719 cites W2004091546 @default.
- W2028874719 cites W2006476048 @default.
- W2028874719 cites W2019104515 @default.
- W2028874719 cites W2032113284 @default.
- W2028874719 cites W2048846412 @default.
- W2028874719 cites W2062819748 @default.
- W2028874719 cites W2068643232 @default.
- W2028874719 cites W2082012658 @default.
- W2028874719 cites W2090805247 @default.
- W2028874719 cites W2168906331 @default.
- W2028874719 cites W92618250 @default.
- W2028874719 doi "https://doi.org/10.1006/abio.2000.4541" @default.
- W2028874719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10790301" @default.
- W2028874719 hasPublicationYear "2000" @default.
- W2028874719 type Work @default.
- W2028874719 sameAs 2028874719 @default.
- W2028874719 citedByCount "9" @default.
- W2028874719 countsByYear W20288747192012 @default.
- W2028874719 countsByYear W20288747192013 @default.
- W2028874719 countsByYear W20288747192015 @default.
- W2028874719 crossrefType "journal-article" @default.
- W2028874719 hasAuthorship W2028874719A5067347941 @default.
- W2028874719 hasAuthorship W2028874719A5076058258 @default.
- W2028874719 hasAuthorship W2028874719A5087101413 @default.
- W2028874719 hasConcept C181199279 @default.
- W2028874719 hasConcept C182220744 @default.
- W2028874719 hasConcept C185592680 @default.
- W2028874719 hasConcept C21951064 @default.
- W2028874719 hasConcept C2776414213 @default.
- W2028874719 hasConcept C2776714187 @default.
- W2028874719 hasConcept C2777807008 @default.
- W2028874719 hasConcept C41183919 @default.
- W2028874719 hasConcept C55493867 @default.
- W2028874719 hasConcept C71240020 @default.
- W2028874719 hasConceptScore W2028874719C181199279 @default.
- W2028874719 hasConceptScore W2028874719C182220744 @default.
- W2028874719 hasConceptScore W2028874719C185592680 @default.
- W2028874719 hasConceptScore W2028874719C21951064 @default.
- W2028874719 hasConceptScore W2028874719C2776414213 @default.
- W2028874719 hasConceptScore W2028874719C2776714187 @default.
- W2028874719 hasConceptScore W2028874719C2777807008 @default.
- W2028874719 hasConceptScore W2028874719C41183919 @default.
- W2028874719 hasConceptScore W2028874719C55493867 @default.
- W2028874719 hasConceptScore W2028874719C71240020 @default.
- W2028874719 hasLocation W20288747191 @default.
- W2028874719 hasLocation W20288747192 @default.
- W2028874719 hasOpenAccess W2028874719 @default.
- W2028874719 hasPrimaryLocation W20288747191 @default.
- W2028874719 hasRelatedWork W1182370503 @default.
- W2028874719 hasRelatedWork W1498441627 @default.
- W2028874719 hasRelatedWork W1979936991 @default.
- W2028874719 hasRelatedWork W1987057684 @default.
- W2028874719 hasRelatedWork W1990623885 @default.
- W2028874719 hasRelatedWork W2016913070 @default.
- W2028874719 hasRelatedWork W2019104515 @default.
- W2028874719 hasRelatedWork W2020508498 @default.
- W2028874719 hasRelatedWork W2025638332 @default.
- W2028874719 hasRelatedWork W2032918269 @default.
- W2028874719 hasRelatedWork W2051337079 @default.
- W2028874719 hasRelatedWork W2071883724 @default.
- W2028874719 hasRelatedWork W2103700658 @default.
- W2028874719 hasRelatedWork W2110323509 @default.
- W2028874719 hasRelatedWork W2138376561 @default.
- W2028874719 hasRelatedWork W2145352278 @default.
- W2028874719 hasRelatedWork W2317774604 @default.
- W2028874719 hasRelatedWork W2950584035 @default.
- W2028874719 hasRelatedWork W3048569867 @default.
- W2028874719 hasRelatedWork W84049265 @default.
- W2028874719 isParatext "false" @default.
- W2028874719 isRetracted "false" @default.
- W2028874719 magId "2028874719" @default.
- W2028874719 workType "article" @default.