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• W2028875463 endingPage "157" @default.
• W2028875463 startingPage "123" @default.
• W2028875463 abstract "Heart transplantation has been performed clinically for four decades, and has become the standard of care for end-stage heart disease. Our understanding of the immunobiology of transplantation has made tremendous strides, but our knowledge still lags behind the clinical use. As a result, nonspecific immunosuppression remains the standard therapy. This chapter is a review of our present knowledge of the immunobiology of allotransplantation and xenotransplantation with emphasis on antigen presentation, costimulation, and T-cell activation in the context of transplantation. The molecular events of T-cell activation, with some emphasis on the sites of action of present day immunosuppression, are reviewed. Basic aspects of immunosuppression are reviewed elsewhere in this edition. Given the paucity of allografts, xenografts are being considered as an alternative donor source. This being the case, cellular and humoral response to xenografts is considered and contrasted with our understanding of allograft immunity. Basic mechanisms of tolerance are discussed, with examples of experimental tolerance induction in small and large animals. A brief description of special considerations for the immunology in human neonate/infant recipients is mentioned. Understanding the immunobiology of transplantation is key to making decisions regarding heart transplant recipients today, in addition to developing better protocols and the induction of tolerance in the future. Heart transplantation has been performed clinically for four decades, and has become the standard of care for end-stage heart disease. Our understanding of the immunobiology of transplantation has made tremendous strides, but our knowledge still lags behind the clinical use. As a result, nonspecific immunosuppression remains the standard therapy. This chapter is a review of our present knowledge of the immunobiology of allotransplantation and xenotransplantation with emphasis on antigen presentation, costimulation, and T-cell activation in the context of transplantation. The molecular events of T-cell activation, with some emphasis on the sites of action of present day immunosuppression, are reviewed. Basic aspects of immunosuppression are reviewed elsewhere in this edition. Given the paucity of allografts, xenografts are being considered as an alternative donor source. This being the case, cellular and humoral response to xenografts is considered and contrasted with our understanding of allograft immunity. Basic mechanisms of tolerance are discussed, with examples of experimental tolerance induction in small and large animals. A brief description of special considerations for the immunology in human neonate/infant recipients is mentioned. Understanding the immunobiology of transplantation is key to making decisions regarding heart transplant recipients today, in addition to developing better protocols and the induction of tolerance in the future." @default.
• W2028875463 created "2016-06-24" @default.
• W2028875463 creator A5018120698 @default.
• W2028875463 creator A5026056715 @default.
• W2028875463 date "2001-01-01" @default.
• W2028875463 modified "2023-10-02" @default.
• W2028875463 title "Immunobiology of Cardiac Allograft and Xenograft Transplantation" @default.
• W2028875463 cites W1479909263 @default.
• W2028875463 cites W1496938524 @default.
• W2028875463 cites W1497417530 @default.
• W2028875463 cites W1499992835 @default.
• W2028875463 cites W1501369169 @default.
• W2028875463 cites W1501518736 @default.
• W2028875463 cites W1501543368 @default.
• W2028875463 cites W1536891815 @default.
• W2028875463 cites W1541421624 @default.
• W2028875463 cites W1543764819 @default.
• W2028875463 cites W1560488739 @default.
• W2028875463 cites W1562057469 @default.
• W2028875463 cites W1576883728 @default.
• W2028875463 cites W1582941402 @default.
• W2028875463 cites W1595539869 @default.
• W2028875463 cites W1607317823 @default.
• W2028875463 cites W1611935467 @default.
• W2028875463 cites W1640952676 @default.
• W2028875463 cites W1652473508 @default.
• W2028875463 cites W1661117573 @default.
• W2028875463 cites W1669165205 @default.
• W2028875463 cites W1677944431 @default.
• W2028875463 cites W1678167583 @default.
• W2028875463 cites W1913508882 @default.
• W2028875463 cites W1964054774 @default.
• W2028875463 cites W1964659945 @default.
• W2028875463 cites W1965593076 @default.
• W2028875463 cites W1966063893 @default.
• W2028875463 cites W1966064095 @default.
• W2028875463 cites W1966818078 @default.
• W2028875463 cites W1967582982 @default.
• W2028875463 cites W1968290615 @default.
• W2028875463 cites W1969210899 @default.
• W2028875463 cites W1969535537 @default.
• W2028875463 cites W1969797237 @default.
• W2028875463 cites W1969868671 @default.
• W2028875463 cites W1969914430 @default.
• W2028875463 cites W1970003185 @default.
• W2028875463 cites W1971026698 @default.
• W2028875463 cites W1971698696 @default.
• W2028875463 cites W1974618020 @default.
• W2028875463 cites W1974783238 @default.
• W2028875463 cites W1976033765 @default.
• W2028875463 cites W1976046966 @default.
• W2028875463 cites W1977298268 @default.
• W2028875463 cites W1978195383 @default.
• W2028875463 cites W1979950065 @default.
• W2028875463 cites W1980897542 @default.
• W2028875463 cites W1983277906 @default.
• W2028875463 cites W1983995896 @default.
• W2028875463 cites W1985774274 @default.
• W2028875463 cites W1986152239 @default.
• W2028875463 cites W1986356667 @default.
• W2028875463 cites W1986487064 @default.
• W2028875463 cites W1986605796 @default.
• W2028875463 cites W1987405127 @default.
• W2028875463 cites W1987712040 @default.
• W2028875463 cites W1989642841 @default.
• W2028875463 cites W1989900422 @default.
• W2028875463 cites W1991209884 @default.
• W2028875463 cites W1991512870 @default.
• W2028875463 cites W1991562873 @default.
• W2028875463 cites W1993188599 @default.
• W2028875463 cites W1995061113 @default.
• W2028875463 cites W1996017127 @default.
• W2028875463 cites W1996451231 @default.
• W2028875463 cites W1998243760 @default.
• W2028875463 cites W1999758832 @default.
• W2028875463 cites W1999999350 @default.
• W2028875463 cites W2000095972 @default.
• W2028875463 cites W2000281244 @default.
• W2028875463 cites W2000517438 @default.
• W2028875463 cites W2001612209 @default.
• W2028875463 cites W2003439719 @default.
• W2028875463 cites W2004005292 @default.
• W2028875463 cites W2004141379 @default.
• W2028875463 cites W2005625705 @default.
• W2028875463 cites W2006084297 @default.
• W2028875463 cites W2006244866 @default.
• W2028875463 cites W2008486184 @default.
• W2028875463 cites W2010488047 @default.
• W2028875463 cites W2010519150 @default.
• W2028875463 cites W2012786710 @default.
• W2028875463 cites W2017025751 @default.
• W2028875463 cites W2017176906 @default.
• W2028875463 cites W2019632210 @default.
• W2028875463 cites W2019899829 @default.
• W2028875463 cites W2020105066 @default.
• W2028875463 cites W2021472475 @default.
• W2028875463 cites W2021884990 @default.
• W2028875463 cites W2023492750 @default.

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