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- W2028884027 abstract "We previously concluded that the Kv2.1 K+ channel inactivates preferentially from partially activated closed states. We report here that the Kv3.1 channel also exhibits two key features of this inactivation mechanism: a U-shaped voltage dependence measured at 10 s and stronger inactivation with repetitive pulses than with a single long depolarization. More surprisingly, slow inactivation of the Kv1 Shaker K+ channel (Shaker BΔ6–46) also has a U-shaped voltage dependence for 10-s depolarizations. The time and voltage dependence of recovery from inactivation reveals two distinct components for Shaker. Strong depolarizations favor inactivation that is reduced by K0+ or by partial block by TEAo, as previously reported for slow inactivation of Shaker. However, depolarizations near 0 mV favor inactivation that recovers rapidly, with strong voltage dependence (as for Kv2.1 and 3.1). The fraction of channels that recover rapidly is increased in TEAo or high K0+. We introduce the term U-type inactivation for the mechanism that is dominant in Kv2.1 and Kv3.1. U-type inactivation also makes a major but previously unrecognized contribution to slow inactivation of Shaker." @default.
- W2028884027 created "2016-06-24" @default.
- W2028884027 creator A5041105135 @default.
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- W2028884027 date "2001-08-01" @default.
- W2028884027 modified "2023-10-12" @default.
- W2028884027 title "U-Type Inactivation of Kv3.1 and Shaker Potassium Channels" @default.
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- W2028884027 doi "https://doi.org/10.1016/s0006-3495(01)75743-8" @default.
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