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- W2028892709 abstract "Foregut drug receptors permit inotropic manipulation of the dysmotility pattern associated with gastroesophageal reflux (GER). Two prokinetic agents, ie. Metoclopramide and Cisapride were assessed in 18 infants with severe GER (mean age 6.5 months) by means of 18-hour continuous intraesophageal pH monitoring. Six parameters were recorded, and the results compared before and during pharmacologic stimulation. Both agents improved the parameters measured, but Cisapride was found to be more effective in enhancing lower esophaeal sphincter competence and esophageal motor function. Long-term assessment of both agents in the management of GER in infants is indicated. Foregut drug receptors permit inotropic manipulation of the dysmotility pattern associated with gastroesophageal reflux (GER). Two prokinetic agents, ie. Metoclopramide and Cisapride were assessed in 18 infants with severe GER (mean age 6.5 months) by means of 18-hour continuous intraesophageal pH monitoring. Six parameters were recorded, and the results compared before and during pharmacologic stimulation. Both agents improved the parameters measured, but Cisapride was found to be more effective in enhancing lower esophaeal sphincter competence and esophageal motor function. Long-term assessment of both agents in the management of GER in infants is indicated." @default.
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- W2028892709 date "1987-10-01" @default.
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- W2028892709 title "Esophageal pH assessment of gastroesophageal reflux in 18 patients and the effect of two prokinetic agents: Cisapride and metoclopramide" @default.
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- W2028892709 doi "https://doi.org/10.1016/s0022-3468(87)80592-4" @default.
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