FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028903713> ?p ?o ?g. }

• W2028903713 endingPage "1491" @default.
• W2028903713 startingPage "1482" @default.
• W2028903713 abstract "Neuropeptide Y (NPY) has been shown to inhibit insulin secretion from the islets of Langerhans. We show that insulin secretion in the insulinoma cell line RIN 5AH is inhibited by NPY. 125I-Peptide YY (PYY) saturation and competition-binding studies using NPY fragments and analogues on membranes prepared from this cell line show the presence of a single class of NPY receptor with a Y1 receptor subtype-like profile. Inhibition of insulin secretion in this cell line by NPY fragments and analogues also shows a Y1 receptor-like profile. Both receptor binding and inhibition of insulin secretion showed the same orders of potency with NPY > [Pro34]-NPY > NPY 3-36 >> NPY 13-36. The Y1 receptor antagonist, BIBP 3226, blocks NPY inhibition of insulin secretion from, and inhibits 125I-PYY binding to, RIN 5AH cells. Northern blot analysis using a Y1-receptor specific probe shows that NPY Y1 receptors are expressed by RIN 5AH cells. Y5 receptors are not expressed in this cell line. Neuropeptide Y inhibition of insulin secretion is blocked by incubation with pertussis toxin, implying that the effect is via a G-protein (Gi or Go) coupled receptor. Neuropeptide Y inhibits the activation of adenylyl cyclase by isoprenaline in RIN 5AH cell lysates, and the stimulation of cAMP by glucagon-like peptide-1 (7-36) amide (GLP-1). It also blocks insulin secretion stimulated by GLP-1, but not by dibutyryl cyclic AMP. Hence, we suggest that NPY inhibits insulin secretion from RIN 5AH cells via a Y1 receptor linked through Gi to the inhibition of adenylyl cyclase." @default.
• W2028903713 created "2016-06-24" @default.
• W2028903713 creator A5009255488 @default.
• W2028903713 creator A5011196462 @default.
• W2028903713 creator A5014580425 @default.
• W2028903713 creator A5042315373 @default.
• W2028903713 creator A5049273814 @default.
• W2028903713 creator A5052975169 @default.
• W2028903713 creator A5060699815 @default.
• W2028903713 creator A5078358960 @default.
• W2028903713 creator A5083682224 @default.
• W2028903713 date "1998-11-23" @default.
• W2028903713 modified "2023-10-16" @default.
• W2028903713 title "Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells" @default.
• W2028903713 cites W1502386136 @default.
• W2028903713 cites W1506043065 @default.
• W2028903713 cites W1509219107 @default.
• W2028903713 cites W1853472159 @default.
• W2028903713 cites W1968818557 @default.
• W2028903713 cites W1974474148 @default.
• W2028903713 cites W1977347031 @default.
• W2028903713 cites W1992013308 @default.
• W2028903713 cites W1999645386 @default.
• W2028903713 cites W2003450342 @default.
• W2028903713 cites W2015917096 @default.
• W2028903713 cites W2016073900 @default.
• W2028903713 cites W2018478659 @default.
• W2028903713 cites W2019491715 @default.
• W2028903713 cites W2024405630 @default.
• W2028903713 cites W2026998012 @default.
• W2028903713 cites W2028319437 @default.
• W2028903713 cites W2043605142 @default.
• W2028903713 cites W2047135359 @default.
• W2028903713 cites W2047773600 @default.
• W2028903713 cites W2048248554 @default.
• W2028903713 cites W2053726057 @default.
• W2028903713 cites W2055355542 @default.
• W2028903713 cites W2055953516 @default.
• W2028903713 cites W2060024636 @default.
• W2028903713 cites W2067096926 @default.
• W2028903713 cites W2069067505 @default.
• W2028903713 cites W2077116170 @default.
• W2028903713 cites W2079083926 @default.
• W2028903713 cites W2079201209 @default.
• W2028903713 cites W2090634763 @default.
• W2028903713 cites W2093132498 @default.
• W2028903713 cites W2095593040 @default.
• W2028903713 cites W2099024620 @default.
• W2028903713 cites W2112171377 @default.
• W2028903713 cites W2125830136 @default.
• W2028903713 cites W2138144765 @default.
• W2028903713 cites W2276502334 @default.
• W2028903713 cites W2335980015 @default.
• W2028903713 cites W2883643415 @default.
• W2028903713 cites W2403957479 @default.
• W2028903713 doi "https://doi.org/10.1007/s001250051095" @default.
• W2028903713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9867216" @default.
• W2028903713 hasPublicationYear "1998" @default.
• W2028903713 type Work @default.
• W2028903713 sameAs 2028903713 @default.
• W2028903713 citedByCount "77" @default.
• W2028903713 countsByYear W20289037132012 @default.
• W2028903713 countsByYear W20289037132013 @default.
• W2028903713 countsByYear W20289037132014 @default.
• W2028903713 countsByYear W20289037132015 @default.
• W2028903713 countsByYear W20289037132016 @default.
• W2028903713 countsByYear W20289037132017 @default.
• W2028903713 countsByYear W20289037132019 @default.
• W2028903713 countsByYear W20289037132020 @default.
• W2028903713 countsByYear W20289037132021 @default.
• W2028903713 countsByYear W20289037132022 @default.
• W2028903713 countsByYear W20289037132023 @default.
• W2028903713 crossrefType "journal-article" @default.
• W2028903713 hasAuthorship W2028903713A5009255488 @default.
• W2028903713 hasAuthorship W2028903713A5011196462 @default.
• W2028903713 hasAuthorship W2028903713A5014580425 @default.
• W2028903713 hasAuthorship W2028903713A5042315373 @default.
• W2028903713 hasAuthorship W2028903713A5049273814 @default.
• W2028903713 hasAuthorship W2028903713A5052975169 @default.
• W2028903713 hasAuthorship W2028903713A5060699815 @default.
• W2028903713 hasAuthorship W2028903713A5078358960 @default.
• W2028903713 hasAuthorship W2028903713A5083682224 @default.
• W2028903713 hasBestOaLocation W20289037131 @default.
• W2028903713 hasConcept C112446052 @default.
• W2028903713 hasConcept C118303440 @default.
• W2028903713 hasConcept C126322002 @default.
• W2028903713 hasConcept C134018914 @default.
• W2028903713 hasConcept C170493617 @default.
• W2028903713 hasConcept C185280430 @default.
• W2028903713 hasConcept C185592680 @default.
• W2028903713 hasConcept C185967709 @default.
• W2028903713 hasConcept C24998067 @default.
• W2028903713 hasConcept C2777391703 @default.
• W2028903713 hasConcept C2778938600 @default.
• W2028903713 hasConcept C2779178603 @default.
• W2028903713 hasConcept C2779306644 @default.
• W2028903713 hasConcept C2780053029 @default.
• W2028903713 hasConcept C2780796126 @default.

• next