FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028904468> ?p ?o ?g. }

• W2028904468 endingPage "210" @default.
• W2028904468 startingPage "200" @default.
• W2028904468 abstract "Inflammation and vascular dysfunction occur concurrently during the prodromal stages of equine laminitis. The aim of this study was to provide insights into the role that thromboxane and isoprostanes may play in the development of black walnut heartwood extract (BWHE)-induced laminitis. Horses were divided into two groups, either control or BWHE-administered horses. Plasma concentrations of thromboxane increased transiently after administration of BWHE and coincided with the nadir in white blood cell counts, whereas plasma concentrations of iso-prostaglandin PGF2α (iso-PGF2α) did not change in either group. At 12 h (for the control group) or Obel grade 1 laminitis (for the BWHE group) the horses were euthanized and laminar tissue collected. Laminar arteries and veins were used in functional studies with vasoconstrictor substances and tissue samples were used for the determination of laminar iso-PGF2α concentrations. Laminar tissue concentrations of iso-PGF2α were significantly greater in BWHE horses when compared to control horses. In parallel studies concentrations of iso-PGF2α in laminar tissue samples obtained 1.5 and 3 h after administration of BWHE were indistinguishable from those for control horses at 3 or 12 h after administration of an equal volume of water. Laminar vessel constrictor responses to either a thromboxane mimetic (U46619), iso-prostaglandin PGE2 (iso-PGE2) or iso-PGF2α were determined using small vessel myographs. In some vessels, the effects of putative prostanoid and thromboxane receptor antagonists, SQ 29,548, SC-19220 and AH 6809, upon contractile responses were determined. In control horses, U46619, iso-PGF2α and iso-PGE2 more potently and efficaciously constricted laminar veins when compared to laminar arteries. Responses of laminar veins from BWHE horses to iso-PGE2 were similar to those of laminar veins from control horses, whereas iso-PGF2α elicited significantly greater responses in laminar veins from BWHE horses when compared to controls. In contrast, responses to U46619 were smaller in laminar veins isolated from BWHE horses when compared to those in laminar veins from control horses. In the presence of SQ 29,548, iso-PGF2α elicited a small dilation in laminar veins from control horses, which was not apparent in laminar veins from BWHE horses. These results are consistent with both systemic and local inflammatory events occurring during the prodromal stages of BWHE-induced laminitis. Because laminar veins are sensitive to thromboxane and isoprostanes, these substances may act as conduits between the inflammatory and vascular events occurring in laminitis and may be therapeutic targets for this crippling condition." @default.
• W2028904468 created "2016-06-24" @default.
• W2028904468 creator A5022861868 @default.
• W2028904468 creator A5031483945 @default.
• W2028904468 creator A5044346916 @default.
• W2028904468 creator A5044445154 @default.
• W2028904468 creator A5067336969 @default.
• W2028904468 creator A5087756137 @default.
• W2028904468 date "2009-06-01" @default.
• W2028904468 modified "2023-10-17" @default.
• W2028904468 title "Thromboxane and isoprostanes as inflammatory and vasoactive mediators in black walnut heartwood extract induced equine laminitis" @default.
• W2028904468 cites W1496181943 @default.
• W2028904468 cites W1906306370 @default.
• W2028904468 cites W1967364641 @default.
• W2028904468 cites W1971598438 @default.
• W2028904468 cites W1972153352 @default.
• W2028904468 cites W1979581142 @default.
• W2028904468 cites W1984240675 @default.
• W2028904468 cites W1988834468 @default.
• W2028904468 cites W1998252647 @default.
• W2028904468 cites W2010447740 @default.
• W2028904468 cites W2017665070 @default.
• W2028904468 cites W2025363673 @default.
• W2028904468 cites W2031602173 @default.
• W2028904468 cites W2033120725 @default.
• W2028904468 cites W2040869820 @default.
• W2028904468 cites W2055553130 @default.
• W2028904468 cites W2061497627 @default.
• W2028904468 cites W2069780385 @default.
• W2028904468 cites W2071111799 @default.
• W2028904468 cites W2074140711 @default.
• W2028904468 cites W2104359627 @default.
• W2028904468 cites W2105697134 @default.
• W2028904468 cites W2117594247 @default.
• W2028904468 cites W2121612337 @default.
• W2028904468 cites W2302373869 @default.
• W2028904468 cites W2394682553 @default.
• W2028904468 cites W2414412491 @default.
• W2028904468 doi "https://doi.org/10.1016/j.vetimm.2008.11.005" @default.
• W2028904468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19111354" @default.
• W2028904468 hasPublicationYear "2009" @default.
• W2028904468 type Work @default.
• W2028904468 sameAs 2028904468 @default.
• W2028904468 citedByCount "27" @default.
• W2028904468 countsByYear W20289044682012 @default.
• W2028904468 countsByYear W20289044682013 @default.
• W2028904468 countsByYear W20289044682015 @default.
• W2028904468 countsByYear W20289044682016 @default.
• W2028904468 countsByYear W20289044682018 @default.
• W2028904468 countsByYear W20289044682019 @default.
• W2028904468 crossrefType "journal-article" @default.
• W2028904468 hasAuthorship W2028904468A5022861868 @default.
• W2028904468 hasAuthorship W2028904468A5031483945 @default.
• W2028904468 hasAuthorship W2028904468A5044346916 @default.
• W2028904468 hasAuthorship W2028904468A5044445154 @default.
• W2028904468 hasAuthorship W2028904468A5067336969 @default.
• W2028904468 hasAuthorship W2028904468A5087756137 @default.
• W2028904468 hasConcept C126322002 @default.
• W2028904468 hasConcept C134018914 @default.
• W2028904468 hasConcept C151730666 @default.
• W2028904468 hasConcept C170493617 @default.
• W2028904468 hasConcept C185592680 @default.
• W2028904468 hasConcept C2776785769 @default.
• W2028904468 hasConcept C2778081065 @default.
• W2028904468 hasConcept C2778266237 @default.
• W2028904468 hasConcept C2780664492 @default.
• W2028904468 hasConcept C2780762169 @default.
• W2028904468 hasConcept C2781024287 @default.
• W2028904468 hasConcept C2781080829 @default.
• W2028904468 hasConcept C71924100 @default.
• W2028904468 hasConcept C86803240 @default.
• W2028904468 hasConcept C89560881 @default.
• W2028904468 hasConceptScore W2028904468C126322002 @default.
• W2028904468 hasConceptScore W2028904468C134018914 @default.
• W2028904468 hasConceptScore W2028904468C151730666 @default.
• W2028904468 hasConceptScore W2028904468C170493617 @default.
• W2028904468 hasConceptScore W2028904468C185592680 @default.
• W2028904468 hasConceptScore W2028904468C2776785769 @default.
• W2028904468 hasConceptScore W2028904468C2778081065 @default.
• W2028904468 hasConceptScore W2028904468C2778266237 @default.
• W2028904468 hasConceptScore W2028904468C2780664492 @default.
• W2028904468 hasConceptScore W2028904468C2780762169 @default.
• W2028904468 hasConceptScore W2028904468C2781024287 @default.
• W2028904468 hasConceptScore W2028904468C2781080829 @default.
• W2028904468 hasConceptScore W2028904468C71924100 @default.
• W2028904468 hasConceptScore W2028904468C86803240 @default.
• W2028904468 hasConceptScore W2028904468C89560881 @default.
• W2028904468 hasIssue "3-4" @default.
• W2028904468 hasLocation W20289044681 @default.
• W2028904468 hasLocation W20289044682 @default.
• W2028904468 hasOpenAccess W2028904468 @default.
• W2028904468 hasPrimaryLocation W20289044681 @default.
• W2028904468 hasRelatedWork W1964674100 @default.
• W2028904468 hasRelatedWork W2004608162 @default.
• W2028904468 hasRelatedWork W2044880765 @default.
• W2028904468 hasRelatedWork W2053182919 @default.
• W2028904468 hasRelatedWork W2077181129 @default.
• W2028904468 hasRelatedWork W2282550390 @default.

• next