Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028921193> ?p ?o ?g. }
- W2028921193 endingPage "790" @default.
- W2028921193 startingPage "783" @default.
- W2028921193 abstract "Objectives: Persistent pain and psychological sequelae are common after motor vehicle collision (MVC), but their etiology remains poorly understood. Such common sequelae include whiplash-associated disorders (WAD), fibromyalgia, and posttraumatic stress disorder (PTSD). Increasing evidence suggests that these disorders share overlapping epidemiologic and clinical features. A model is proposed in which central neurobiological systems, including physiologic systems and neuroanatomical structures involved in the stress response, are an important substrate for the development of all 3 disorders and interact with psychosocial and other factors to influence chronic symptom development. Methods: Epidemiologic and clinical characteristics regarding the development of these disorders after MVC are reviewed. Evidence suggesting a role for stress response systems in the development of these disorders is presented. Results: Contemporary evidence supports a model of chronic symptom development that incorporates the potential for interactions between past experience, acute stress responses to trauma, post-MVC behavior, and cognitive/psychosocial consequences to alter activity within brain regions which process pain and to result in persistent pain, as well as psychological sequelae, after MVC. Such a model incorporates factors identified in prior biopsychosocial theories and places them in the landscape of our rapidly developing understanding of stress systems and CNS pain-modulating pathways. Conclusion: New models are needed to stimulate deeper examination of the interacting influences of initial tissue damage, acute pain, psychosocial contingencies, and central stress pathways during chronic symptom development after MVC. Deeper understanding could contribute to improved treatment approaches to reduce the immense personal and societal burdens of common trauma-related disorders. CRH = corticotrophin-releasing hormone; MVC = motor vehicle collision; WAD = whiplash-associated disorders; PTSD = posttraumatic stress disorder; HPA = hypothalamic-pituitary-adrenal; LC/NE=locus ceruleus/norepinephrine-sympathetic." @default.
- W2028921193 created "2016-06-24" @default.
- W2028921193 creator A5003434684 @default.
- W2028921193 creator A5042130258 @default.
- W2028921193 creator A5055323138 @default.
- W2028921193 creator A5075081932 @default.
- W2028921193 date "2005-09-01" @default.
- W2028921193 modified "2023-10-14" @default.
- W2028921193 title "The Development of Persistent Pain and Psychological Morbidity After Motor Vehicle Collision: Integrating the Potential Role of Stress Response Systems Into a Biopsychosocial Model" @default.
- W2028921193 cites W107097692 @default.
- W2028921193 cites W1529535966 @default.
- W2028921193 cites W1565463643 @default.
- W2028921193 cites W171228341 @default.
- W2028921193 cites W1743523990 @default.
- W2028921193 cites W1793086031 @default.
- W2028921193 cites W1967791807 @default.
- W2028921193 cites W1970986955 @default.
- W2028921193 cites W1972075157 @default.
- W2028921193 cites W1973734624 @default.
- W2028921193 cites W1980239413 @default.
- W2028921193 cites W1984295229 @default.
- W2028921193 cites W1988031794 @default.
- W2028921193 cites W1991218534 @default.
- W2028921193 cites W1994463719 @default.
- W2028921193 cites W1999628906 @default.
- W2028921193 cites W2004303942 @default.
- W2028921193 cites W2004398848 @default.
- W2028921193 cites W2005533083 @default.
- W2028921193 cites W2009219892 @default.
- W2028921193 cites W2010384223 @default.
- W2028921193 cites W2014523693 @default.
- W2028921193 cites W2014845285 @default.
- W2028921193 cites W2016432478 @default.
- W2028921193 cites W2016748877 @default.
- W2028921193 cites W2017238102 @default.
- W2028921193 cites W2018677176 @default.
- W2028921193 cites W2018851494 @default.
- W2028921193 cites W2020433551 @default.
- W2028921193 cites W2026219727 @default.
- W2028921193 cites W2026396276 @default.
- W2028921193 cites W2026412977 @default.
- W2028921193 cites W2027861855 @default.
- W2028921193 cites W2031041075 @default.
- W2028921193 cites W2031076299 @default.
- W2028921193 cites W2035853448 @default.
- W2028921193 cites W2035946659 @default.
- W2028921193 cites W2036704853 @default.
- W2028921193 cites W2037712619 @default.
- W2028921193 cites W2038065324 @default.
- W2028921193 cites W2039835743 @default.
- W2028921193 cites W2041269877 @default.
- W2028921193 cites W2047196117 @default.
- W2028921193 cites W2049883541 @default.
- W2028921193 cites W2053618648 @default.
- W2028921193 cites W2054977744 @default.
- W2028921193 cites W2055456847 @default.
- W2028921193 cites W2055772777 @default.
- W2028921193 cites W2062700118 @default.
- W2028921193 cites W2065195473 @default.
- W2028921193 cites W2067858950 @default.
- W2028921193 cites W2068368851 @default.
- W2028921193 cites W2068392981 @default.
- W2028921193 cites W2069336217 @default.
- W2028921193 cites W2070017221 @default.
- W2028921193 cites W2073376147 @default.
- W2028921193 cites W2077666777 @default.
- W2028921193 cites W2078085488 @default.
- W2028921193 cites W2082139480 @default.
- W2028921193 cites W2083113027 @default.
- W2028921193 cites W2085210590 @default.
- W2028921193 cites W2089613636 @default.
- W2028921193 cites W2090446436 @default.
- W2028921193 cites W2095239761 @default.
- W2028921193 cites W2099093791 @default.
- W2028921193 cites W2100791720 @default.
- W2028921193 cites W2107676335 @default.
- W2028921193 cites W2108571323 @default.
- W2028921193 cites W2114214919 @default.
- W2028921193 cites W2114943199 @default.
- W2028921193 cites W2123611093 @default.
- W2028921193 cites W2124205347 @default.
- W2028921193 cites W2124257779 @default.
- W2028921193 cites W2127070740 @default.
- W2028921193 cites W2128109138 @default.
- W2028921193 cites W2128472215 @default.
- W2028921193 cites W2129727087 @default.
- W2028921193 cites W2133756419 @default.
- W2028921193 cites W2135000045 @default.
- W2028921193 cites W2141935057 @default.
- W2028921193 cites W2143103188 @default.
- W2028921193 cites W2144933081 @default.
- W2028921193 cites W2147572597 @default.
- W2028921193 cites W2151099642 @default.
- W2028921193 cites W2151437219 @default.
- W2028921193 cites W2164806392 @default.
- W2028921193 cites W2253364553 @default.
- W2028921193 cites W2329414057 @default.
- W2028921193 cites W4233270027 @default.