FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028931639> ?p ?o ?g. }

• W2028931639 endingPage "1426" @default.
• W2028931639 startingPage "1411" @default.
• W2028931639 abstract "Summary Coxiella burnetii , a Gram‐negative obligate intracellular pathogen, replicates within an parasitophorous vacuole with lysosomal characteristics. To understand how C. burnetii maintains genomic integrity in this environment, a database search for genes involved in DNA repair was performed. Major components of repair, SOS response and recombination were identified, including recA and ruvABC , but lexA and recBCD were absent. Instead, C. burnetii possesses addAB orthologous genes, functional equivalents to recBCD . Survival after treatment with UV, mitomycin C (MC) or methyl methanesulfonate (MMS), as well as homologous recombination in Hfr mating was restored in Escherichia coli deletion strains by C. burnetii recA or addAB . Despite the absence of LexA, co‐protease activity for C. burnetii RecA was demonstrated. Dominant‐negative inhibition of C. burnetii RecA by recA mutant alleles, modelled after E. coli recA1 and recA56 , was observed and more apparent with expression of C. burnetii RecAG159D mutant protein. Expression of a subset of repair genes in C. burnetii was monitored and, in contrast to the non‐inducible E. coli recBCD , addAB expression was strongly upregulated under oxidative stress. Constitutive SOS gene expression due to the lack of LexA and induction of AddAB likely reflect a unique repair adaptation of C. burnetii to its hostile niche." @default.
• W2028931639 created "2016-06-24" @default.
• W2028931639 creator A5024602262 @default.
• W2028931639 creator A5044013608 @default.
• W2028931639 creator A5044549524 @default.
• W2028931639 creator A5066607950 @default.
• W2028931639 date "2008-08-21" @default.
• W2028931639 modified "2023-09-30" @default.
• W2028931639 title "Constitutive SOS expression and damage-inducible AddAB-mediated recombinational repair systems for<i>Coxiella burnetii</i>as potential adaptations for survival within macrophages" @default.
• W2028931639 cites W1483522581 @default.
• W2028931639 cites W1497274060 @default.
• W2028931639 cites W1662809715 @default.
• W2028931639 cites W1685911874 @default.
• W2028931639 cites W1833676004 @default.
• W2028931639 cites W1859044233 @default.
• W2028931639 cites W1880802239 @default.
• W2028931639 cites W1940324517 @default.
• W2028931639 cites W1941875646 @default.
• W2028931639 cites W1967705460 @default.
• W2028931639 cites W1969896631 @default.
• W2028931639 cites W1977890732 @default.
• W2028931639 cites W1979243502 @default.
• W2028931639 cites W2004101198 @default.
• W2028931639 cites W2010740375 @default.
• W2028931639 cites W2014358885 @default.
• W2028931639 cites W2025900361 @default.
• W2028931639 cites W2028544954 @default.
• W2028931639 cites W2042055876 @default.
• W2028931639 cites W2047841570 @default.
• W2028931639 cites W2053781861 @default.
• W2028931639 cites W2054941036 @default.
• W2028931639 cites W2065667431 @default.
• W2028931639 cites W2065688789 @default.
• W2028931639 cites W2075122383 @default.
• W2028931639 cites W2080709317 @default.
• W2028931639 cites W2080871509 @default.
• W2028931639 cites W2085719068 @default.
• W2028931639 cites W2097466384 @default.
• W2028931639 cites W2097525601 @default.
• W2028931639 cites W2101091447 @default.
• W2028931639 cites W2101108802 @default.
• W2028931639 cites W2105698198 @default.
• W2028931639 cites W2109336572 @default.
• W2028931639 cites W2109753782 @default.
• W2028931639 cites W2111593608 @default.
• W2028931639 cites W2114449759 @default.
• W2028931639 cites W2115693680 @default.
• W2028931639 cites W2118764553 @default.
• W2028931639 cites W2123063744 @default.
• W2028931639 cites W2125214142 @default.
• W2028931639 cites W2125537048 @default.
• W2028931639 cites W2134903749 @default.
• W2028931639 cites W2143669599 @default.
• W2028931639 cites W2145304961 @default.
• W2028931639 cites W2148057452 @default.
• W2028931639 cites W2152424070 @default.
• W2028931639 cites W2152845055 @default.
• W2028931639 cites W2153218617 @default.
• W2028931639 cites W2155563816 @default.
• W2028931639 cites W2158293863 @default.
• W2028931639 cites W2164013467 @default.
• W2028931639 cites W2401756795 @default.
• W2028931639 cites W4211219679 @default.
• W2028931639 doi "https://doi.org/10.1111/j.1365-2958.2008.06373.x" @default.
• W2028931639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18647165" @default.
• W2028931639 hasPublicationYear "2008" @default.
• W2028931639 type Work @default.
• W2028931639 sameAs 2028931639 @default.
• W2028931639 citedByCount "39" @default.
• W2028931639 countsByYear W20289316392012 @default.
• W2028931639 countsByYear W20289316392013 @default.
• W2028931639 countsByYear W20289316392014 @default.
• W2028931639 countsByYear W20289316392015 @default.
• W2028931639 countsByYear W20289316392016 @default.
• W2028931639 countsByYear W20289316392017 @default.
• W2028931639 countsByYear W20289316392018 @default.
• W2028931639 countsByYear W20289316392019 @default.
• W2028931639 countsByYear W20289316392020 @default.
• W2028931639 countsByYear W20289316392021 @default.
• W2028931639 countsByYear W20289316392022 @default.
• W2028931639 countsByYear W20289316392023 @default.
• W2028931639 crossrefType "journal-article" @default.
• W2028931639 hasAuthorship W2028931639A5024602262 @default.
• W2028931639 hasAuthorship W2028931639A5044013608 @default.
• W2028931639 hasAuthorship W2028931639A5044549524 @default.
• W2028931639 hasAuthorship W2028931639A5066607950 @default.
• W2028931639 hasBestOaLocation W20289316391 @default.
• W2028931639 hasConcept C101762097 @default.
• W2028931639 hasConcept C104317684 @default.
• W2028931639 hasConcept C134935766 @default.
• W2028931639 hasConcept C143065580 @default.
• W2028931639 hasConcept C150194340 @default.
• W2028931639 hasConcept C153911025 @default.
• W2028931639 hasConcept C158448853 @default.
• W2028931639 hasConcept C174742784 @default.
• W2028931639 hasConcept C2776607032 @default.
• W2028931639 hasConcept C2777712861 @default.
• W2028931639 hasConcept C2778758119 @default.

• next