FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028937551> ?p ?o ?g. }

• W2028937551 endingPage "98" @default.
• W2028937551 startingPage "88" @default.
• W2028937551 abstract "Myofibroblast apoptosis promotes the resolution of liver fibrosis. However, retaining macrophages may enhance reversal. The effects of specifically stimulating myofibroblast apoptosis in vivo were assessed.A single chain antibody (C1-3) to an extracellular domain of a myofibroblast membrane protein was injected as a fluorescent- or gliotoxin conjugate into mice with liver fibrosis.C1-3 specifically targeted alpha-smooth muscle actin positive liver myofibroblasts within scar regions of the liver in vivo and did not co-localise with liver monocytes/macrophages. Injection of free gliotoxin stimulated a 2-fold increase in non-parenchymal cell apoptosis and depleted liver myofibroblasts by 30% and monocytes/macrophages by 50% but had no effect on fibrosis severity in the sustained injury model employed. In contrast, C1-3-targeted gliotoxin stimulated a 5-fold increase in non-parenchymal cell apoptosis, depleted liver myofibroblasts by 60%, did not affect the number of monocytes/macrophages and significantly reduced fibrosis severity. Fibrosis reduction was associated with increased metalloproteinase-13 levels.These data demonstrate that specific targeting of liver myofibroblast apoptosis is the most effective anti-fibrogenic therapy, supporting a role for liver monocytes and/or macrophages in the promotion of liver fibrosis reduction." @default.
• W2028937551 created "2016-06-24" @default.
• W2028937551 creator A5012516965 @default.
• W2028937551 creator A5025968524 @default.
• W2028937551 creator A5028020059 @default.
• W2028937551 creator A5031218409 @default.
• W2028937551 creator A5038882357 @default.
• W2028937551 creator A5062550860 @default.
• W2028937551 creator A5065189960 @default.
• W2028937551 creator A5079532494 @default.
• W2028937551 creator A5083531495 @default.
• W2028937551 date "2008-07-01" @default.
• W2028937551 modified "2023-10-01" @default.
• W2028937551 title "Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury" @default.
• W2028937551 cites W1547216586 @default.
• W2028937551 cites W1957112060 @default.
• W2028937551 cites W1965568495 @default.
• W2028937551 cites W1968460020 @default.
• W2028937551 cites W1976809932 @default.
• W2028937551 cites W1979372049 @default.
• W2028937551 cites W1983653895 @default.
• W2028937551 cites W1989696056 @default.
• W2028937551 cites W1993340412 @default.
• W2028937551 cites W1993698899 @default.
• W2028937551 cites W1996027317 @default.
• W2028937551 cites W1997064567 @default.
• W2028937551 cites W2005025375 @default.
• W2028937551 cites W2005263248 @default.
• W2028937551 cites W2018225189 @default.
• W2028937551 cites W2027684983 @default.
• W2028937551 cites W2032743420 @default.
• W2028937551 cites W2045280576 @default.
• W2028937551 cites W2070583931 @default.
• W2028937551 cites W2076517608 @default.
• W2028937551 cites W2081670575 @default.
• W2028937551 cites W2082401103 @default.
• W2028937551 cites W2083410657 @default.
• W2028937551 cites W2088724129 @default.
• W2028937551 cites W2093862280 @default.
• W2028937551 cites W2098193724 @default.
• W2028937551 cites W2116937468 @default.
• W2028937551 cites W2118206305 @default.
• W2028937551 cites W2136017162 @default.
• W2028937551 cites W2140711940 @default.
• W2028937551 cites W2154992735 @default.
• W2028937551 cites W2156646628 @default.
• W2028937551 cites W2157852745 @default.
• W2028937551 cites W2161803404 @default.
• W2028937551 cites W2165062244 @default.
• W2028937551 cites W2179353943 @default.
• W2028937551 cites W4250007760 @default.
• W2028937551 doi "https://doi.org/10.1016/j.jhep.2008.01.032" @default.
• W2028937551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18394744" @default.
• W2028937551 hasPublicationYear "2008" @default.
• W2028937551 type Work @default.
• W2028937551 sameAs 2028937551 @default.
• W2028937551 citedByCount "79" @default.
• W2028937551 countsByYear W20289375512012 @default.
• W2028937551 countsByYear W20289375512013 @default.
• W2028937551 countsByYear W20289375512014 @default.
• W2028937551 countsByYear W20289375512015 @default.
• W2028937551 countsByYear W20289375512016 @default.
• W2028937551 countsByYear W20289375512017 @default.
• W2028937551 countsByYear W20289375512018 @default.
• W2028937551 countsByYear W20289375512019 @default.
• W2028937551 countsByYear W20289375512020 @default.
• W2028937551 countsByYear W20289375512021 @default.
• W2028937551 countsByYear W20289375512022 @default.
• W2028937551 countsByYear W20289375512023 @default.
• W2028937551 crossrefType "journal-article" @default.
• W2028937551 hasAuthorship W2028937551A5012516965 @default.
• W2028937551 hasAuthorship W2028937551A5025968524 @default.
• W2028937551 hasAuthorship W2028937551A5028020059 @default.
• W2028937551 hasAuthorship W2028937551A5031218409 @default.
• W2028937551 hasAuthorship W2028937551A5038882357 @default.
• W2028937551 hasAuthorship W2028937551A5062550860 @default.
• W2028937551 hasAuthorship W2028937551A5065189960 @default.
• W2028937551 hasAuthorship W2028937551A5079532494 @default.
• W2028937551 hasAuthorship W2028937551A5083531495 @default.
• W2028937551 hasConcept C126322002 @default.
• W2028937551 hasConcept C142724271 @default.
• W2028937551 hasConcept C150903083 @default.
• W2028937551 hasConcept C176891718 @default.
• W2028937551 hasConcept C190283241 @default.
• W2028937551 hasConcept C203014093 @default.
• W2028937551 hasConcept C207001950 @default.
• W2028937551 hasConcept C207865475 @default.
• W2028937551 hasConcept C2776637226 @default.
• W2028937551 hasConcept C2777183694 @default.
• W2028937551 hasConcept C2779787849 @default.
• W2028937551 hasConcept C2780559512 @default.
• W2028937551 hasConcept C502942594 @default.
• W2028937551 hasConcept C55493867 @default.
• W2028937551 hasConcept C71924100 @default.
• W2028937551 hasConcept C86803240 @default.
• W2028937551 hasConceptScore W2028937551C126322002 @default.
• W2028937551 hasConceptScore W2028937551C142724271 @default.
• W2028937551 hasConceptScore W2028937551C150903083 @default.

• next