Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028944098> ?p ?o ?g. }
- W2028944098 endingPage "66" @default.
- W2028944098 startingPage "55" @default.
- W2028944098 abstract "The ion channels expressed by T lymphocytes play key roles in the control of the membrane potential and calcium signaling, thereby affecting signal transduction pathways that lead to the activation of these cells following antigenic stimulation. Disruption of these pathways can attenuate or prevent the response of T-cells to antigenic challenge resulting in immune suppression. Studies using ion channel blockers of high affinity and specificity have shown that this interference can be achieved at the level of ion channels. Suppression of immune functions by channel blockers has been demonstrated in vitro and in vivo. New information about the molecular structure of ion channels facilitates the design of more potent and more specific inhibitors. Thus, T-cell ion channels are likely to serve as targets for immunomodulatory drugs in the near future. Here, the biophysical properties, tissue distribution, regulation of expression, molecular pharmacology and role in T-cell activation of the voltage-gated Kv1.3 and the Ca2+-activated IKCa1 potassium channels and those of the Ca+ release-activated Ca2+ (CRAC) channel are reviewed." @default.
- W2028944098 created "2016-06-24" @default.
- W2028944098 creator A5021200075 @default.
- W2028944098 creator A5043019374 @default.
- W2028944098 creator A5052648785 @default.
- W2028944098 date "2004-03-29" @default.
- W2028944098 modified "2023-10-15" @default.
- W2028944098 title "Ion channels and lymphocyte activation" @default.
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