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• W2028949566 startingPage "125" @default.
• W2028949566 abstract "The current use and future perspectives of molecular genetic characterisation of cytochrome P450 enzymes (CYP) for drug development and drug treatment are summarised. CYP genes are highly polymorphic and the enzymes play a key role in the elimination of the majority of drugs from the human body. Frequent variants of some enzymes, CYP2A6, 2C9, 2C19 and 2D6, should be analysed in participants of clinical trials whenever these enzymes may play a role. It is suggested that a CYP genotype certificate is handed out to the volunteers or patients to avoid replicate analyses, and to allow that this information is available for future research and also for treatment with eventually needed drugs. Guidelines on what CYP alleles have to be analysed in drug development, as well as on analytical validation and CYP genotype data handling will be required. Treatment with several drugs may be improved by prior genotyping. The concepts and problems of CYP genotype-based clinical dose recommendations are presented and illustrated for selected drugs. The requirement for prospective trials on the medical and economic benefits of routine CYP genotyping is emphasised. Specific operationally defined recommendations dependent on genotype are a prerequisite for such studies and this review presents tentative CYP genotype-based dose recommendations systematically calculated from published data. Because of the multiplicity of factors involved, these doses will not be the optimal doses for each given individual, but should be more adequate than doses generally recommended for an average total population. Those CYP alleles and polymorphically metabolised drugs which are currently most interesting in drug development and drug treatment are reviewed, and more complete information is available from websites cited in this article." @default.
• W2028949566 created "2016-06-24" @default.
• W2028949566 creator A5001414279 @default.
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• W2028949566 creator A5069451422 @default.
• W2028949566 date "2000-05-01" @default.
• W2028949566 modified "2023-10-12" @default.
• W2028949566 title "Pharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment" @default.
• W2028949566 cites W1502407336 @default.
• W2028949566 cites W1508691659 @default.
• W2028949566 cites W1584188206 @default.
• W2028949566 cites W1914476337 @default.
• W2028949566 cites W1964688493 @default.
• W2028949566 cites W1966008148 @default.
• W2028949566 cites W1968212253 @default.
• W2028949566 cites W1971536751 @default.
• W2028949566 cites W1972053711 @default.
• W2028949566 cites W1973644343 @default.
• W2028949566 cites W1973751472 @default.
• W2028949566 cites W1976138388 @default.
• W2028949566 cites W1979090325 @default.
• W2028949566 cites W1979259734 @default.
• W2028949566 cites W1980050671 @default.
• W2028949566 cites W1980643683 @default.
• W2028949566 cites W1982290436 @default.
• W2028949566 cites W1986443718 @default.
• W2028949566 cites W1986838867 @default.
• W2028949566 cites W1989868874 @default.
• W2028949566 cites W1991163272 @default.
• W2028949566 cites W1991626196 @default.
• W2028949566 cites W1992040236 @default.
• W2028949566 cites W1998573208 @default.
• W2028949566 cites W1999173998 @default.
• W2028949566 cites W2000967958 @default.
• W2028949566 cites W2002779112 @default.
• W2028949566 cites W2003020809 @default.
• W2028949566 cites W2004352153 @default.
• W2028949566 cites W2004557299 @default.
• W2028949566 cites W2006998778 @default.
• W2028949566 cites W2008516711 @default.
• W2028949566 cites W2009765984 @default.
• W2028949566 cites W2010724535 @default.
• W2028949566 cites W2011258029 @default.
• W2028949566 cites W2011403103 @default.
• W2028949566 cites W2016911934 @default.
• W2028949566 cites W2019337449 @default.
• W2028949566 cites W2020000231 @default.
• W2028949566 cites W2022486010 @default.
• W2028949566 cites W2024171602 @default.
• W2028949566 cites W2024819714 @default.
• W2028949566 cites W2025332743 @default.
• W2028949566 cites W2031625516 @default.
• W2028949566 cites W2031804700 @default.
• W2028949566 cites W2033564508 @default.
• W2028949566 cites W2034595467 @default.
• W2028949566 cites W2040950569 @default.
• W2028949566 cites W2045221999 @default.
• W2028949566 cites W2045273410 @default.
• W2028949566 cites W2047209698 @default.
• W2028949566 cites W2048793396 @default.
• W2028949566 cites W2048808087 @default.
• W2028949566 cites W2049377642 @default.
• W2028949566 cites W2049881228 @default.
• W2028949566 cites W2049976899 @default.
• W2028949566 cites W2054458932 @default.
• W2028949566 cites W2055568229 @default.
• W2028949566 cites W2057845591 @default.
• W2028949566 cites W2059680081 @default.
• W2028949566 cites W2063261636 @default.
• W2028949566 cites W2064096935 @default.
• W2028949566 cites W2065976317 @default.
• W2028949566 cites W2068520564 @default.
• W2028949566 cites W2071332031 @default.
• W2028949566 cites W2071847493 @default.
• W2028949566 cites W2071953688 @default.
• W2028949566 cites W2075503758 @default.
• W2028949566 cites W2075634729 @default.
• W2028949566 cites W2076350936 @default.
• W2028949566 cites W2076934626 @default.
• W2028949566 cites W2076998901 @default.
• W2028949566 cites W2086415080 @default.
• W2028949566 cites W2086968218 @default.
• W2028949566 cites W2087096604 @default.
• W2028949566 cites W2089082398 @default.
• W2028949566 cites W2090814473 @default.
• W2028949566 cites W2090876589 @default.
• W2028949566 cites W2092510009 @default.
• W2028949566 cites W2094212245 @default.
• W2028949566 cites W2094353948 @default.
• W2028949566 cites W2099420087 @default.
• W2028949566 cites W2111073764 @default.
• W2028949566 cites W2119499480 @default.
• W2028949566 cites W2131933646 @default.
• W2028949566 cites W2145370692 @default.
• W2028949566 cites W2145804143 @default.
• W2028949566 cites W2149319043 @default.
• W2028949566 cites W2150738344 @default.

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