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- W2028952661 abstract "In Reply. —Several factors including differences in cotinine elimination between smokers and nonsmokers, 1 physicochemical differences between mainstream and sidestream smoke 2,3 and variance in mode of uptake of carcinogenic and cocarcinogenic compounds in mainstream and sidestream smoke lead us to maintain that a direct extrapolation to cigarette equivalents of inhaled smoke cannot be validated in nonsmokers from a single measurement of urinary cotinine. Enlarging on the data presented in our report, we have confirmed a longer residence time for cotinine in the urine of exposed nonsmokers compared with smokers and have observed interindividual variation in both groups. 4,5 This variation does not permit a magnitude of difference to be established. Comparing urine cotinine half-life in three studies, we see ratios of 1.3, 6 1.5, 1 and 1.7, 4,5 indicating 30%, 50%, and 70% differences in average urine values. Additionally, urine cotinine half-lives of 66 hours have been reported in" @default.
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- W2028952661 date "1988-03-25" @default.
- W2028952661 modified "2023-10-18" @default.
- W2028952661 title "Use of Urinary Cotinine to Estimate Exposure to Tobacco Smoke-Reply" @default.
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- W2028952661 doi "https://doi.org/10.1001/jama.1988.03720120016014" @default.
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