FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028956384> ?p ?o ?g. }

• W2028956384 endingPage "646" @default.
• W2028956384 startingPage "637" @default.
• W2028956384 abstract "Antisense oligodeoxynucleotides (ODNs) are synthetic molecules typically designed to hybridise to the sense strand of the target gene messenger RNA (mRNA). The activity of these molecules reduces gene expression by disrupting the flow of information from gene to protein. The specificity of this interaction arises from the antisense ODN having a unique affinity for the primary sequence of the target gene due to nucleotide base complementarity. Specific inhibition of target gene products allows a rapidly increasing number of researchers to investigate gene function. Additionally, the reversible and specific nature of this interaction has initiated interest in antisense ODNs as a potentially novel class of therapeutics. Antisense molecules are already undergoing clinical trials as candidate therapeutics for several indications. Recent advances in our understanding of the activity of antisense ODNs, together with the advances in ODN chemistry, has made the notion of therapeutically active antisense molecules realistic. However, there remain many challenges in this field which must be overcome. Notably, the most commonly used chemical class of antisense ODNs, the phosphorothioates, has been associated with significant non-specific activities. This brief review aims to present in vivo applications of antisense in the domains of both basic and clinical research." @default.
• W2028956384 created "2016-06-24" @default.
• W2028956384 creator A5012210717 @default.
• W2028956384 creator A5063089135 @default.
• W2028956384 date "1995-07-01" @default.
• W2028956384 modified "2023-09-25" @default.
• W2028956384 title "Section Review: Biologicals & Immunologicals: Applications of antisense technology to both basic and clinical research" @default.
• W2028956384 cites W1240040893 @default.
• W2028956384 cites W1435647736 @default.
• W2028956384 cites W1468684175 @default.
• W2028956384 cites W1521664811 @default.
• W2028956384 cites W1598096558 @default.
• W2028956384 cites W1911219124 @default.
• W2028956384 cites W1929805927 @default.
• W2028956384 cites W1963859585 @default.
• W2028956384 cites W1969818257 @default.
• W2028956384 cites W1969909813 @default.
• W2028956384 cites W1970650788 @default.
• W2028956384 cites W1971597849 @default.
• W2028956384 cites W1972147130 @default.
• W2028956384 cites W1972380716 @default.
• W2028956384 cites W1972724663 @default.
• W2028956384 cites W1973546377 @default.
• W2028956384 cites W1975614725 @default.
• W2028956384 cites W1977698865 @default.
• W2028956384 cites W1981481692 @default.
• W2028956384 cites W1985408811 @default.
• W2028956384 cites W1987135690 @default.
• W2028956384 cites W1988369548 @default.
• W2028956384 cites W1990548509 @default.
• W2028956384 cites W1994090158 @default.
• W2028956384 cites W1995599027 @default.
• W2028956384 cites W2005333148 @default.
• W2028956384 cites W2006239014 @default.
• W2028956384 cites W2006367248 @default.
• W2028956384 cites W2007404424 @default.
• W2028956384 cites W2017567167 @default.
• W2028956384 cites W2020570530 @default.
• W2028956384 cites W2021015782 @default.
• W2028956384 cites W2022495840 @default.
• W2028956384 cites W2025997520 @default.
• W2028956384 cites W2028544691 @default.
• W2028956384 cites W2028804525 @default.
• W2028956384 cites W2031092694 @default.
• W2028956384 cites W2034487226 @default.
• W2028956384 cites W2034908174 @default.
• W2028956384 cites W2042715440 @default.
• W2028956384 cites W2050014764 @default.
• W2028956384 cites W2064087831 @default.
• W2028956384 cites W2067193940 @default.
• W2028956384 cites W2067401769 @default.
• W2028956384 cites W2068230814 @default.
• W2028956384 cites W2070000321 @default.
• W2028956384 cites W2075033137 @default.
• W2028956384 cites W2076885147 @default.
• W2028956384 cites W2078571233 @default.
• W2028956384 cites W2079242913 @default.
• W2028956384 cites W2079803201 @default.
• W2028956384 cites W2082965230 @default.
• W2028956384 cites W2084901266 @default.
• W2028956384 cites W2086140963 @default.
• W2028956384 cites W2091128862 @default.
• W2028956384 cites W2091599040 @default.
• W2028956384 cites W2113567410 @default.
• W2028956384 cites W2117082238 @default.
• W2028956384 cites W2152855538 @default.
• W2028956384 cites W2159869413 @default.
• W2028956384 cites W2184197616 @default.
• W2028956384 cites W2394507820 @default.
• W2028956384 cites W2404119433 @default.
• W2028956384 doi "https://doi.org/10.1517/13543784.4.7.637" @default.
• W2028956384 hasPublicationYear "1995" @default.
• W2028956384 type Work @default.
• W2028956384 sameAs 2028956384 @default.
• W2028956384 citedByCount "3" @default.
• W2028956384 crossrefType "journal-article" @default.
• W2028956384 hasAuthorship W2028956384A5012210717 @default.
• W2028956384 hasAuthorship W2028956384A5063089135 @default.
• W2028956384 hasConcept C104317684 @default.
• W2028956384 hasConcept C105580179 @default.
• W2028956384 hasConcept C111599444 @default.
• W2028956384 hasConcept C14036430 @default.
• W2028956384 hasConcept C143141573 @default.
• W2028956384 hasConcept C14363569 @default.
• W2028956384 hasConcept C147789679 @default.
• W2028956384 hasConcept C150194340 @default.
• W2028956384 hasConcept C185592680 @default.
• W2028956384 hasConcept C202416437 @default.
• W2028956384 hasConcept C2908938912 @default.
• W2028956384 hasConcept C54355233 @default.
• W2028956384 hasConcept C67705224 @default.
• W2028956384 hasConcept C70721500 @default.
• W2028956384 hasConcept C86803240 @default.
• W2028956384 hasConcept C95444343 @default.
• W2028956384 hasConcept C95911042 @default.
• W2028956384 hasConceptScore W2028956384C104317684 @default.
• W2028956384 hasConceptScore W2028956384C105580179 @default.
• W2028956384 hasConceptScore W2028956384C111599444 @default.

• next