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• W2028966110 abstract "(+)-1'-[4-Hydroxy-1-(4-fluorobenzyl)piperidin-3-yl]spiro[1H- indene-1,4'- piperidine] {(+)-Spiro-FBT}, a high-affinity vesicular acetylcholine transporter ligand, was labeled with fluorine-18, and evaluated in the rat and monkey. In the rat brain, (+)-[18F]Spiro-FBT accumulated preferentially in the striatum, hippocampus, and cortex, brains regions containing high-to-moderate densities of cholinergic terminals. However, due to rapid metabolism, no preferential accumulation of the radiotracer was observed in corresponding regions of the monkey brain. Consequently, rapid metabolism renders (+)-[18F]Spiro-FBT unsuitable for studying cholinergic function with positron emission tomography." @default.
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• W2028966110 date "1999-02-01" @default.
• W2028966110 modified "2023-09-27" @default.
• W2028966110 title "(+)-p-([18F]fluorobenzyl)spirotrozamicol {(+)-[18F]Spiro-FBT}: synthesis and biological evaluation of a high-affinity ligand for the vesicular acetylcholine transporter (VAChT)" @default.
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• W2028966110 doi "https://doi.org/10.1016/s0969-8051(98)00090-0" @default.
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