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- W2028971323 endingPage "254" @default.
- W2028971323 startingPage "237" @default.
- W2028971323 abstract "A centrally important factor in initiating egg activation at fertilization is a rise in free Ca(2+) in the egg cytosol. In echinoderm, ascidian, and vertebrate eggs, the Ca(2+) rise occurs as a result of inositol trisphosphate-mediated release of Ca(2+) from the endoplasmic reticulum. The release of Ca(2+) at fertilization in echinoderm and ascidian eggs requires SH2 domain-mediated activation of a Src family kinase (SFK) and phospholipase C (PLC)gamma. Though some evidence indicates that a SFK and PLC may also function at fertilization in vertebrate eggs, SH2 domain-mediated activation of PLC gamma appears not to be required. Much work has focused on identifying factors from sperm that initiate egg activation at fertilization, either as a result of sperm-egg contact or sperm-egg fusion. Current evidence from studies of ascidian and mammalian fertilization favors a fusion-mediated mechanism; this is supported by experiments indicating that injection of sperm extracts into eggs causes Ca(2+) release by the same pathway as fertilization." @default.
- W2028971323 created "2016-06-24" @default.
- W2028971323 creator A5059667030 @default.
- W2028971323 creator A5063587977 @default.
- W2028971323 creator A5081630269 @default.
- W2028971323 date "2002-05-01" @default.
- W2028971323 modified "2023-10-11" @default.
- W2028971323 title "Egg Activation at Fertilization: Where It All Begins" @default.
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