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• W2028976945 endingPage "128" @default.
• W2028976945 startingPage "63" @default.
• W2028976945 abstract "Important insights into leukocyte differentiation and the cellular origins of leukemia and lymphoma have been gained through the use of monoclonal antibodies that define cell surface antigens and molecular probes that identify immunoglobulin and T-cell receptor genes. Results of these studies have been combined with markers such as surface membrane and cytoplasmic immunoglobulin on B lymphocytes, sheep erythrocyte receptors on T lymphocytes, and cytochemical stains. After using all of the aforementioned markers, it is now clear that acute lymphoblastic leukemia (ALL) is heterogeneous. Furthermore, monoclonal antibodies that identify B cells, such as the anti-CD20 and anti-CD19 antibodies in combination with studies of immunoglobulin gene rearrangement, have demonstrated that virtually all cases of non-T-ALL are malignancies of B-cell origin. At least six distinct subgroups of non-T-ALL can now be identified. T-ALL is subdivided by the anti-CD7, anti-CD5, and antibodies that separate T lymphocytes subsets into three primary subgroups. Monoclonal antibodies are also useful in the subclassification of non-Hodgkin's lymphoma, and certain distinct markers can be correlated with morphological classification. Although monoclonal antibodies are useful in distinguishing acute myeloid from acute lymphoid leukemias, they have less certain utility in the subclassification of acute myelogenous leukemia (AML). Attempts to subclassify AML by differentiation-associated antigens rather than by the French-American-British (FAB) classification are underway in order to document the potential prognostic utility of surface markers. Therapeutic trials using monoclonal antibodies in leukemia and lymphoma have been reported. Intravenous infusion of unlabeled antibodies is the most widely used method; transient responses have been demonstrated. Antibodies conjugated to radionuclides have been quite successful in localizing tumors of less than 1 cm in some studies. Therapy trials with antibodies conjugated to isotopes, toxins, and drugs have shown promise. Purging of autologous bone marrow with monoclonal antibodies and complement in vitro has been used in ALL and non-Hodgkin's lymphoma; preliminary data suggest that this approach may be an effective therapy and may circumvent many of the obstacles and toxicities associated with in vivo monoclonal antibody infusion." @default.
• W2028976945 created "2016-06-24" @default.
• W2028976945 creator A5073403338 @default.
• W2028976945 date "1989-03-01" @default.
• W2028976945 modified "2023-09-28" @default.
• W2028976945 title "Laboratory and clinical applications of monoclonal antibodies for leukemias and non-Hodkin's lymphoma" @default.
• W2028976945 cites W112706474 @default.
• W2028976945 cites W137281929 @default.
• W2028976945 cites W137400728 @default.
• W2028976945 cites W1490675470 @default.
• W2028976945 cites W1493755175 @default.
• W2028976945 cites W1508716863 @default.
• W2028976945 cites W151600129 @default.
• W2028976945 cites W1525297399 @default.
• W2028976945 cites W1533561364 @default.
• W2028976945 cites W1533725999 @default.
• W2028976945 cites W1554197358 @default.
• W2028976945 cites W1564446535 @default.
• W2028976945 cites W1564925934 @default.
• W2028976945 cites W1567474693 @default.
• W2028976945 cites W1573027401 @default.
• W2028976945 cites W1588212475 @default.
• W2028976945 cites W1596160021 @default.
• W2028976945 cites W1598656612 @default.
• W2028976945 cites W1604484135 @default.
• W2028976945 cites W1622869137 @default.
• W2028976945 cites W177560736 @default.
• W2028976945 cites W180597183 @default.
• W2028976945 cites W1826412460 @default.
• W2028976945 cites W1839751882 @default.
• W2028976945 cites W1839771299 @default.
• W2028976945 cites W18518170 @default.
• W2028976945 cites W188885646 @default.
• W2028976945 cites W1897300991 @default.
• W2028976945 cites W1945721659 @default.
• W2028976945 cites W1964202604 @default.
• W2028976945 cites W1964395467 @default.
• W2028976945 cites W1964571831 @default.
• W2028976945 cites W1965958875 @default.
• W2028976945 cites W1966240406 @default.
• W2028976945 cites W1967227139 @default.
• W2028976945 cites W1969578383 @default.
• W2028976945 cites W1969669223 @default.
• W2028976945 cites W1969783034 @default.
• W2028976945 cites W1971790285 @default.
• W2028976945 cites W1973761389 @default.
• W2028976945 cites W1974430798 @default.
• W2028976945 cites W1974957197 @default.
• W2028976945 cites W1976209387 @default.
• W2028976945 cites W1981062512 @default.
• W2028976945 cites W1981319123 @default.
• W2028976945 cites W1982738964 @default.
• W2028976945 cites W1984724325 @default.
• W2028976945 cites W1988416931 @default.
• W2028976945 cites W1988483221 @default.
• W2028976945 cites W1989400464 @default.
• W2028976945 cites W1989671244 @default.
• W2028976945 cites W1990073813 @default.
• W2028976945 cites W1992000854 @default.
• W2028976945 cites W1993603685 @default.
• W2028976945 cites W1993632984 @default.
• W2028976945 cites W1994199468 @default.
• W2028976945 cites W1995981815 @default.
• W2028976945 cites W1995986183 @default.
• W2028976945 cites W1997309117 @default.
• W2028976945 cites W1997869886 @default.
• W2028976945 cites W1998717119 @default.
• W2028976945 cites W2000991239 @default.
• W2028976945 cites W2002594142 @default.
• W2028976945 cites W2004106131 @default.
• W2028976945 cites W2004523292 @default.
• W2028976945 cites W200635427 @default.
• W2028976945 cites W2006470316 @default.
• W2028976945 cites W2007643304 @default.
• W2028976945 cites W2011553631 @default.
• W2028976945 cites W2013486805 @default.
• W2028976945 cites W2013676976 @default.
• W2028976945 cites W2016832598 @default.
• W2028976945 cites W2016919816 @default.
• W2028976945 cites W2017963255 @default.
• W2028976945 cites W2018821773 @default.
• W2028976945 cites W2021339636 @default.
• W2028976945 cites W2023277714 @default.
• W2028976945 cites W2024721190 @default.
• W2028976945 cites W2025630928 @default.
• W2028976945 cites W2027922729 @default.
• W2028976945 cites W2028145249 @default.
• W2028976945 cites W2029042799 @default.
• W2028976945 cites W2030522563 @default.
• W2028976945 cites W2031726826 @default.
• W2028976945 cites W2033644503 @default.
• W2028976945 cites W2036404799 @default.
• W2028976945 cites W2036479586 @default.
• W2028976945 cites W2037127970 @default.
• W2028976945 cites W2038165289 @default.
• W2028976945 cites W2038340428 @default.
• W2028976945 cites W2038682313 @default.
• W2028976945 cites W2040505042 @default.

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