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- W2028981962 abstract "The distribution of calcitonin-gene-related peptide-like immunoreactivity (CGRP-IR) was studied in sections of decalcified rat head and selected whole-mount preparations in order to address the complex peptidergic innervation patterns in peripheral cephalic specialized zones and to examine neuronal ganglia in situ. Labeled neuron somata in trigeminal, glossopharyngeal, and vagal ganglia comprised a large proportion of small to medium size type B ganglion cells. Parasympathetic ganglia (ciliary, otic, sphenopalatine, submandibular) revealed a small population of labeled somata and numerous perisomatic IR axons, whereas sympathetic ganglion cells (superior cervical) were devoid of label though richly innervated by perisomatic IR axons. The gustatory geniculate ganglion contained only a few labeled neurons and axons. Coarse peripheral CGRP-IR axons were traced to skeletal muscle motor end plates (e.g., lingual, tensor tympani, etc.), and thin sensory axons most densely innervated the cornea, iris, general integument, all mucosal epithelia lining the tympanic, nasal, sinus and oropharyngeal cavities, and the cerebral meninges. Blood vessels, glands, ducts, and their orifices were often heavily innervated, and specific specializations and exceptions are discussed. Distinctive patterns of IR innervation characterized the various specialized sensory systems, including 1) cochlear and vestibular hair cells; 2) lingual, palatal, oropharyngeal, and laryngoepiglottal taste buds; 3) main olfactory epithelium and axons projecting to glomeruli in specific sectors of main olfactory bulb; 4) septal-olfactory organ; 5) vomeronasal organ; and 6) the nervus terminalis system. Secretory epithelia (ciliary body, choroid plexus, and stria vascularis) were notably lacking in CGRP-IR. Despite the multiplicity of functionally distinct CGRP neuronal and axonal populations, certain generalizations merit consideration. The extensive innervation of chemosensory nasal and oral epithelia may contribute to specific chemical sensitivities (e.g., relating to olfactory and gustatory senses) as well as evoking nociceptive responses to chemical irritants as part of a common chemical sense. An efferent role for some of these peptidergic afferent axons may also be inferred from their specific distributions. Sites involved in regulating access to and sensitivity of sense organs to external stimuli (e.g., cochlear and vestibular hair cells, taste bud orifices, and main olfactory epithelium) are heavily innervated. Other IR axons are in position to exert control over airflow through nasal turbinates, glandular secretion, blood circulation, and duct transport systems.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
- W2028981962 created "2016-06-24" @default.
- W2028981962 creator A5005390808 @default.
- W2028981962 creator A5007218513 @default.
- W2028981962 date "1989-02-08" @default.
- W2028981962 modified "2023-10-14" @default.
- W2028981962 title "Calcitonin-gene-related-peptide-immunoreactive innervation of the rat head with emphasis on specialized sensory structures" @default.
- W2028981962 cites W1506673182 @default.
- W2028981962 cites W1574220069 @default.
- W2028981962 cites W1603227402 @default.
- W2028981962 cites W1669628027 @default.
- W2028981962 cites W1876814577 @default.
- W2028981962 cites W1917144620 @default.
- W2028981962 cites W1957319743 @default.
- W2028981962 cites W1964323548 @default.
- W2028981962 cites W1966100112 @default.
- W2028981962 cites W1966418285 @default.
- W2028981962 cites W1968549810 @default.
- W2028981962 cites W1970509343 @default.
- W2028981962 cites W1972010931 @default.
- W2028981962 cites W1972320412 @default.
- W2028981962 cites W1973603846 @default.
- W2028981962 cites W1973806783 @default.
- W2028981962 cites W1973955512 @default.
- W2028981962 cites W1974749992 @default.
- W2028981962 cites W1976482893 @default.
- W2028981962 cites W1977326055 @default.
- W2028981962 cites W1977527684 @default.
- W2028981962 cites W1978409519 @default.
- W2028981962 cites W1978843266 @default.
- W2028981962 cites W1979110856 @default.
- W2028981962 cites W1982265488 @default.
- W2028981962 cites W1984457601 @default.
- W2028981962 cites W1984875213 @default.
- W2028981962 cites W1987211178 @default.
- W2028981962 cites W1991637403 @default.
- W2028981962 cites W1993891259 @default.
- W2028981962 cites W1994334620 @default.
- W2028981962 cites W1996026062 @default.
- W2028981962 cites W1996942493 @default.
- W2028981962 cites W1997715882 @default.
- W2028981962 cites W1999147380 @default.
- W2028981962 cites W2000614632 @default.
- W2028981962 cites W2000700430 @default.
- W2028981962 cites W2001385401 @default.
- W2028981962 cites W2002628912 @default.
- W2028981962 cites W2003270321 @default.
- W2028981962 cites W2008269409 @default.
- W2028981962 cites W2009451039 @default.
- W2028981962 cites W2010530616 @default.
- W2028981962 cites W2011671563 @default.
- W2028981962 cites W2012748943 @default.
- W2028981962 cites W2012923655 @default.
- W2028981962 cites W2016299086 @default.
- W2028981962 cites W2020335694 @default.
- W2028981962 cites W2020919581 @default.
- W2028981962 cites W2024069034 @default.
- W2028981962 cites W2024525681 @default.
- W2028981962 cites W2027187874 @default.
- W2028981962 cites W2029780099 @default.
- W2028981962 cites W2033080361 @default.
- W2028981962 cites W2034261131 @default.
- W2028981962 cites W2034659798 @default.
- W2028981962 cites W2035324492 @default.
- W2028981962 cites W2035581625 @default.
- W2028981962 cites W2035720315 @default.
- W2028981962 cites W2038753552 @default.
- W2028981962 cites W2039881419 @default.
- W2028981962 cites W2041751593 @default.
- W2028981962 cites W2043196553 @default.
- W2028981962 cites W2043314709 @default.
- W2028981962 cites W2043506549 @default.
- W2028981962 cites W2046731801 @default.
- W2028981962 cites W2047121327 @default.
- W2028981962 cites W2048359466 @default.
- W2028981962 cites W2049018037 @default.
- W2028981962 cites W2049282640 @default.
- W2028981962 cites W2049821020 @default.
- W2028981962 cites W2050635513 @default.
- W2028981962 cites W2050895773 @default.
- W2028981962 cites W2051296824 @default.
- W2028981962 cites W2053277833 @default.
- W2028981962 cites W2053883183 @default.
- W2028981962 cites W2054732165 @default.
- W2028981962 cites W2054978714 @default.
- W2028981962 cites W2055999131 @default.
- W2028981962 cites W2056715444 @default.
- W2028981962 cites W2057559921 @default.
- W2028981962 cites W2058630627 @default.
- W2028981962 cites W2061436780 @default.
- W2028981962 cites W2064644119 @default.
- W2028981962 cites W2065948307 @default.
- W2028981962 cites W2067524401 @default.
- W2028981962 cites W2067699638 @default.
- W2028981962 cites W2068155648 @default.
- W2028981962 cites W2068290015 @default.
- W2028981962 cites W2068538069 @default.
- W2028981962 cites W2069252221 @default.