FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028986505> ?p ?o ?g. }

• W2028986505 abstract "The new molecular entity quinoxalinhydrazide derivative NVX-412 was identified as a promising drug candidate for the treatment of various cancer types due to its strong cytotoxic activity and relative specificity. Here, we provide first data about the mechanisms of action of NVX-412. We show that NVX-412 exerts its anti-neoplastic activity in a p53-independent manner and induces S-phase arrest and DNA damage as assessed by γH2AX staining. We suggest a bi-modal (dose-dependent) mode of action of NVX-412, being primarily cytostatic at lower and predominantly cytotoxic at higher concentrations. Based on the broad and consistent anti-neoplastic activity observed, NVX-412 holds promise as an effective drug candidate for the treatment of various cancer types, especially for hematological malignancies with highly unmet medical need." @default.
• W2028986505 created "2016-06-24" @default.
• W2028986505 creator A5002123126 @default.
• W2028986505 creator A5070993361 @default.
• W2028986505 creator A5076152154 @default.
• W2028986505 date "2012-09-13" @default.
• W2028986505 modified "2023-09-26" @default.
• W2028986505 title "NVX-412, a New Oncology Drug Candidate, Induces S-Phase Arrest and DNA Damage in Cancer Cells in a p53-Independent Manner" @default.
• W2028986505 cites W114060563 @default.
• W2028986505 cites W1564224574 @default.
• W2028986505 cites W1967803195 @default.
• W2028986505 cites W1970924670 @default.
• W2028986505 cites W1970963436 @default.
• W2028986505 cites W1978873740 @default.
• W2028986505 cites W1981413140 @default.
• W2028986505 cites W1982122127 @default.
• W2028986505 cites W1986076152 @default.
• W2028986505 cites W1988349429 @default.
• W2028986505 cites W1990481297 @default.
• W2028986505 cites W2000206408 @default.
• W2028986505 cites W2015341962 @default.
• W2028986505 cites W2023623233 @default.
• W2028986505 cites W2028282498 @default.
• W2028986505 cites W2030877568 @default.
• W2028986505 cites W2039937583 @default.
• W2028986505 cites W2052674054 @default.
• W2028986505 cites W2068307354 @default.
• W2028986505 cites W2079744186 @default.
• W2028986505 cites W2087312216 @default.
• W2028986505 cites W2097933346 @default.
• W2028986505 cites W2100737258 @default.
• W2028986505 cites W2101065496 @default.
• W2028986505 cites W2106888057 @default.
• W2028986505 cites W2110010650 @default.
• W2028986505 cites W2111091957 @default.
• W2028986505 cites W2118106551 @default.
• W2028986505 cites W2132834292 @default.
• W2028986505 cites W2134319564 @default.
• W2028986505 cites W2135732933 @default.
• W2028986505 cites W2139151018 @default.
• W2028986505 cites W2139354073 @default.
• W2028986505 cites W2146274229 @default.
• W2028986505 cites W2320337269 @default.
• W2028986505 doi "https://doi.org/10.1371/journal.pone.0045015" @default.
• W2028986505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3441706" @default.
• W2028986505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23028738" @default.
• W2028986505 hasPublicationYear "2012" @default.
• W2028986505 type Work @default.
• W2028986505 sameAs 2028986505 @default.
• W2028986505 citedByCount "4" @default.
• W2028986505 countsByYear W20289865052014 @default.
• W2028986505 countsByYear W20289865052016 @default.
• W2028986505 countsByYear W20289865052020 @default.
• W2028986505 crossrefType "journal-article" @default.
• W2028986505 hasAuthorship W2028986505A5002123126 @default.
• W2028986505 hasAuthorship W2028986505A5070993361 @default.
• W2028986505 hasAuthorship W2028986505A5076152154 @default.
• W2028986505 hasBestOaLocation W20289865051 @default.
• W2028986505 hasConcept C121587506 @default.
• W2028986505 hasConcept C121608353 @default.
• W2028986505 hasConcept C143425029 @default.
• W2028986505 hasConcept C154317977 @default.
• W2028986505 hasConcept C202751555 @default.
• W2028986505 hasConcept C2780035454 @default.
• W2028986505 hasConcept C33070731 @default.
• W2028986505 hasConcept C502942594 @default.
• W2028986505 hasConcept C54355233 @default.
• W2028986505 hasConcept C552990157 @default.
• W2028986505 hasConcept C86803240 @default.
• W2028986505 hasConcept C96232424 @default.
• W2028986505 hasConcept C98274493 @default.
• W2028986505 hasConceptScore W2028986505C121587506 @default.
• W2028986505 hasConceptScore W2028986505C121608353 @default.
• W2028986505 hasConceptScore W2028986505C143425029 @default.
• W2028986505 hasConceptScore W2028986505C154317977 @default.
• W2028986505 hasConceptScore W2028986505C202751555 @default.
• W2028986505 hasConceptScore W2028986505C2780035454 @default.
• W2028986505 hasConceptScore W2028986505C33070731 @default.
• W2028986505 hasConceptScore W2028986505C502942594 @default.
• W2028986505 hasConceptScore W2028986505C54355233 @default.
• W2028986505 hasConceptScore W2028986505C552990157 @default.
• W2028986505 hasConceptScore W2028986505C86803240 @default.
• W2028986505 hasConceptScore W2028986505C96232424 @default.
• W2028986505 hasConceptScore W2028986505C98274493 @default.
• W2028986505 hasLocation W20289865051 @default.
• W2028986505 hasLocation W20289865052 @default.
• W2028986505 hasLocation W20289865053 @default.
• W2028986505 hasLocation W20289865054 @default.
• W2028986505 hasLocation W20289865055 @default.
• W2028986505 hasOpenAccess W2028986505 @default.
• W2028986505 hasPrimaryLocation W20289865051 @default.
• W2028986505 hasRelatedWork W1531992803 @default.
• W2028986505 hasRelatedWork W1631113354 @default.
• W2028986505 hasRelatedWork W2005618894 @default.
• W2028986505 hasRelatedWork W2008853985 @default.
• W2028986505 hasRelatedWork W2023967169 @default.
• W2028986505 hasRelatedWork W2049808254 @default.
• W2028986505 hasRelatedWork W2062808499 @default.
• W2028986505 hasRelatedWork W2077391866 @default.
• W2028986505 hasRelatedWork W2098457059 @default.

• next