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- W2028991508 abstract "Aims . Our objective was to examine Apo J protein expression in a total of 27 early liveborn neonatal deaths (less than 7 days of age) selected from the Scottish Perinatal Study (gestation of 25–42 weeks) comparing a group with histological pontosubicular necrosis (PSN) () to a control group lacking PSN (). Methods . Using immunohistochemistry we evaluated postmortem pons and hippocampus from patients with PSN versus controls. Results . In the group with PSN, 11/12 (92%) cases showed positive Apo J neurones in the hippocampus/pons compared with 6/15 (40%) cases without PSN (, odds ratio 27.5, 95% confidence interval 2.881–262.48, using exact logistic regression)—independent of gestation, presence or absence of clinical asphyxia, duration of labour, or postnatal age. Clinical asphyxia was present in 10/15 (67%) without PSN compared with 11/12 (92%) with PSN. Neuronal Apo J positivity was present in 15/21 (71%) of clinically asphyxiated cases compared with 2/6 (33%) of the cases with no evidence of clinical asphyxia (, odds ratio 5, 95% confidence interval 0.71 to 34.94). Conclusions . Apo J neuronal protein expression is significantly increased in cases with PSN compared to cases without PSN—independent of gestation, presence of clinical asphyxia, duration of labour, or postnatal age." @default.
- W2028991508 created "2016-06-24" @default.
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- W2028991508 date "2012-07-12" @default.
- W2028991508 modified "2023-09-27" @default.
- W2028991508 title "Retrospective Case-Control Study of Apolipoprotein J/Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis" @default.
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- W2028991508 doi "https://doi.org/10.1155/2012/479359" @default.
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