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• W2028992775 abstract "Treatment with interferon-α (IFN-α) was undertaken in 16 patients with human T-lymphotropic virus type I-associated myelopathy (HAM). All patients had progressive spastic paraparesis before treatment. Twelve patients were enrolled in an open therapeutic trial with a dose of 3.0 × 106 IU/day of IFN-α and 4 in a randomized, double-blind, multidose (3.0 × 106, 1.0 × 106 or 0.3 × 106 IU/day) trial. IFN-α was injected intramuscularly for 28 days. Eight of 12 patients enrolled in an open trial and 2 patients receiving a dose of 3.0 × 106 IU/day of IFN-α in a randomized trial showed clinical improvements during and after the treatment. The results showed that, although not for all patients, systemic IFN-α with a dose of 3.0 × 106 IU/day is effective in the treatment of HAM." @default.
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• W2028992775 date "1992-07-01" @default.
• W2028992775 modified "2023-09-27" @default.
• W2028992775 title "Systemic interferon-alpha in the treatment of HTLV-I-associated myelopathy" @default.
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• W2028992775 doi "https://doi.org/10.1111/j.1600-0404.1992.tb08059.x" @default.
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