FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028993885> ?p ?o ?g. }

• W2028993885 endingPage "622" @default.
• W2028993885 startingPage "613" @default.
• W2028993885 abstract "Summary Objective In multiple endocrine neoplasia type 1 (MEN1), age‐related tumour penetrance according to the type of MEN1 germline mutation has not been investigated in‐depth. This study was conducted to examine whether carriers of out‐of‐frame/truncating and in‐frame MEN1 mutations differ in age‐related tumour penetrance. Design A multicentre study with biochemical, hormonal and radiological screening for MEN1‐associated tumours. Patients A total of 258 MEN1 carriers from six major German tertiary referral centres averaging 43 years of age at last follow‐up. Measurements Main outcome measure was time to first diagnosis of MEN1‐associated tumours. Results Independent of the year of birth and observation period, time to first tumour diagnosis did not vary much by the type of MEN1 germline mutation or endocrine organ system, and perhaps not even by the type of endocrine tumour when the amount of time was considered by which the diagnosis probably has been advanced through the manifestation of hormonal symptoms. Parathyroid hyperplasia and adenomas developed almost twice as often as enteropancreatic and pituitary tumours (77% vs . 49–32%), and more than five to sevenfold as often as adrenal cortical tumours and carcinoids (77% vs . 15–10%), reaching penetrance rates of up to 90%, 60%, 40%, 26% and 17%, respectively. The heterogeneity of tumour penetrance was marked, ranging from 9 years to 25 years for the earliest, and from 68 years to 77 years for the latest tumour manifestation. Conclusions Because of our inability of predicting tumour penetrance and malignant transformation individually, life‐long follow‐up of MEN1 carriers is warranted to prevent tumour morbidity." @default.
• W2028993885 created "2016-06-24" @default.
• W2028993885 creator A5006595466 @default.
• W2028993885 creator A5012039621 @default.
• W2028993885 creator A5018194984 @default.
• W2028993885 creator A5029171467 @default.
• W2028993885 creator A5039893902 @default.
• W2028993885 creator A5040072236 @default.
• W2028993885 creator A5053015594 @default.
• W2028993885 creator A5087571933 @default.
• W2028993885 creator A5088849267 @default.
• W2028993885 creator A5089879417 @default.
• W2028993885 date "2007-05-30" @default.
• W2028993885 modified "2023-10-15" @default.
• W2028993885 title "Age-related penetrance of endocrine tumours in multiple endocrine neoplasia type 1 (MEN1): a multicentre study of 258 gene carriers" @default.
• W2028993885 cites W1968558567 @default.
• W2028993885 cites W1971960595 @default.
• W2028993885 cites W1973333569 @default.
• W2028993885 cites W1988517195 @default.
• W2028993885 cites W1990696436 @default.
• W2028993885 cites W1994350448 @default.
• W2028993885 cites W2002633572 @default.
• W2028993885 cites W2014386433 @default.
• W2028993885 cites W2028009104 @default.
• W2028993885 cites W2034599110 @default.
• W2028993885 cites W2051900545 @default.
• W2028993885 cites W2052847071 @default.
• W2028993885 cites W2057168818 @default.
• W2028993885 cites W2058174004 @default.
• W2028993885 cites W2073332144 @default.
• W2028993885 cites W2111159251 @default.
• W2028993885 cites W2111301538 @default.
• W2028993885 cites W2111914269 @default.
• W2028993885 cites W2114578972 @default.
• W2028993885 cites W2117829134 @default.
• W2028993885 cites W2125989442 @default.
• W2028993885 cites W2133348390 @default.
• W2028993885 cites W2142747205 @default.
• W2028993885 cites W2146718153 @default.
• W2028993885 cites W2150111853 @default.
• W2028993885 cites W2150212366 @default.
• W2028993885 cites W2157212789 @default.
• W2028993885 cites W2162942974 @default.
• W2028993885 cites W2314635417 @default.
• W2028993885 cites W4243314716 @default.
• W2028993885 cites W4293241248 @default.
• W2028993885 doi "https://doi.org/10.1111/j.1365-2265.2007.02934.x" @default.
• W2028993885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17590169" @default.
• W2028993885 hasPublicationYear "2007" @default.
• W2028993885 type Work @default.
• W2028993885 sameAs 2028993885 @default.
• W2028993885 citedByCount "79" @default.
• W2028993885 countsByYear W20289938852012 @default.
• W2028993885 countsByYear W20289938852013 @default.
• W2028993885 countsByYear W20289938852014 @default.
• W2028993885 countsByYear W20289938852015 @default.
• W2028993885 countsByYear W20289938852016 @default.
• W2028993885 countsByYear W20289938852017 @default.
• W2028993885 countsByYear W20289938852018 @default.
• W2028993885 countsByYear W20289938852019 @default.
• W2028993885 countsByYear W20289938852020 @default.
• W2028993885 countsByYear W20289938852021 @default.
• W2028993885 countsByYear W20289938852022 @default.
• W2028993885 countsByYear W20289938852023 @default.
• W2028993885 crossrefType "journal-article" @default.
• W2028993885 hasAuthorship W2028993885A5006595466 @default.
• W2028993885 hasAuthorship W2028993885A5012039621 @default.
• W2028993885 hasAuthorship W2028993885A5018194984 @default.
• W2028993885 hasAuthorship W2028993885A5029171467 @default.
• W2028993885 hasAuthorship W2028993885A5039893902 @default.
• W2028993885 hasAuthorship W2028993885A5040072236 @default.
• W2028993885 hasAuthorship W2028993885A5053015594 @default.
• W2028993885 hasAuthorship W2028993885A5087571933 @default.
• W2028993885 hasAuthorship W2028993885A5088849267 @default.
• W2028993885 hasAuthorship W2028993885A5089879417 @default.
• W2028993885 hasConcept C104317684 @default.
• W2028993885 hasConcept C126322002 @default.
• W2028993885 hasConcept C127716648 @default.
• W2028993885 hasConcept C134018914 @default.
• W2028993885 hasConcept C13514818 @default.
• W2028993885 hasConcept C142724271 @default.
• W2028993885 hasConcept C143998085 @default.
• W2028993885 hasConcept C200544954 @default.
• W2028993885 hasConcept C2779469564 @default.
• W2028993885 hasConcept C2780103800 @default.
• W2028993885 hasConcept C46699223 @default.
• W2028993885 hasConcept C501734568 @default.
• W2028993885 hasConcept C54355233 @default.
• W2028993885 hasConcept C71315377 @default.
• W2028993885 hasConcept C71924100 @default.
• W2028993885 hasConcept C86803240 @default.
• W2028993885 hasConceptScore W2028993885C104317684 @default.
• W2028993885 hasConceptScore W2028993885C126322002 @default.
• W2028993885 hasConceptScore W2028993885C127716648 @default.
• W2028993885 hasConceptScore W2028993885C134018914 @default.
• W2028993885 hasConceptScore W2028993885C13514818 @default.
• W2028993885 hasConceptScore W2028993885C142724271 @default.
• W2028993885 hasConceptScore W2028993885C143998085 @default.

• next