Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028994032> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2028994032 abstract "Activated protein C (APC) is an anticoagulant polypeptide that plays a critical role in coagulation, inflammation and anticoagulation interactions; in addition, it decreases the mortality rate of patients with severe infectious disease. However, the exact mechanisms of these effects remain unclear. The aim of this study was to investigate the effect of APC on human umbilical vein endothelial cell apoptosis upon lipopolysaccharide (LPS) stimulation and to elucidate its underlying mechanisms. Apoptotic changes in cells were determined by examining cell ultra-structure, DNA fragmentation and Annexin V/PI staining. Cell viability and the expression of apoptotic-related factors were measured in LPS-stimulated cells with and without APC treatment. The results showed that the administration of APC decreased the apoptosis of cells by inhibiting the activity of the caspase-3 apoptotic-signaling pathway in LPS-stimulated cells. This study supports the notion that APC treatment may be beneficial for the attenuation of endothelial cell injury caused by severe infectious disease via the regulation of apoptotic pathways. Furthermore, APC may be useful in the treatment of infectious disease." @default.
- W2028994032 created "2016-06-24" @default.
- W2028994032 creator A5008456162 @default.
- W2028994032 creator A5008544946 @default.
- W2028994032 creator A5053119996 @default.
- W2028994032 creator A5056399898 @default.
- W2028994032 creator A5081860423 @default.
- W2028994032 date "2010-09-10" @default.
- W2028994032 modified "2023-09-28" @default.
- W2028994032 title "Anti-apoptotic effect of activated protein C on lipopolysaccharide-stimulated human umbilical vein endothelial cells is associated with the inhibition of the caspase-3 pathway" @default.
- W2028994032 doi "https://doi.org/10.3892/mmr.2010.359" @default.
- W2028994032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21472345" @default.
- W2028994032 hasPublicationYear "2010" @default.
- W2028994032 type Work @default.
- W2028994032 sameAs 2028994032 @default.
- W2028994032 citedByCount "0" @default.
- W2028994032 crossrefType "journal-article" @default.
- W2028994032 hasAuthorship W2028994032A5008456162 @default.
- W2028994032 hasAuthorship W2028994032A5008544946 @default.
- W2028994032 hasAuthorship W2028994032A5053119996 @default.
- W2028994032 hasAuthorship W2028994032A5056399898 @default.
- W2028994032 hasAuthorship W2028994032A5081860423 @default.
- W2028994032 hasBestOaLocation W20289940321 @default.
- W2028994032 hasConcept C123012128 @default.
- W2028994032 hasConcept C1491633281 @default.
- W2028994032 hasConcept C190283241 @default.
- W2028994032 hasConcept C202751555 @default.
- W2028994032 hasConcept C203014093 @default.
- W2028994032 hasConcept C2777411675 @default.
- W2028994032 hasConcept C2778754761 @default.
- W2028994032 hasConcept C2780670749 @default.
- W2028994032 hasConcept C29537977 @default.
- W2028994032 hasConcept C31573885 @default.
- W2028994032 hasConcept C43759708 @default.
- W2028994032 hasConcept C502942594 @default.
- W2028994032 hasConcept C55493867 @default.
- W2028994032 hasConcept C86803240 @default.
- W2028994032 hasConcept C88634738 @default.
- W2028994032 hasConcept C95444343 @default.
- W2028994032 hasConceptScore W2028994032C123012128 @default.
- W2028994032 hasConceptScore W2028994032C1491633281 @default.
- W2028994032 hasConceptScore W2028994032C190283241 @default.
- W2028994032 hasConceptScore W2028994032C202751555 @default.
- W2028994032 hasConceptScore W2028994032C203014093 @default.
- W2028994032 hasConceptScore W2028994032C2777411675 @default.
- W2028994032 hasConceptScore W2028994032C2778754761 @default.
- W2028994032 hasConceptScore W2028994032C2780670749 @default.
- W2028994032 hasConceptScore W2028994032C29537977 @default.
- W2028994032 hasConceptScore W2028994032C31573885 @default.
- W2028994032 hasConceptScore W2028994032C43759708 @default.
- W2028994032 hasConceptScore W2028994032C502942594 @default.
- W2028994032 hasConceptScore W2028994032C55493867 @default.
- W2028994032 hasConceptScore W2028994032C86803240 @default.
- W2028994032 hasConceptScore W2028994032C88634738 @default.
- W2028994032 hasConceptScore W2028994032C95444343 @default.
- W2028994032 hasLocation W20289940321 @default.
- W2028994032 hasLocation W20289940322 @default.
- W2028994032 hasOpenAccess W2028994032 @default.
- W2028994032 hasPrimaryLocation W20289940321 @default.
- W2028994032 hasRelatedWork W1999578065 @default.
- W2028994032 hasRelatedWork W2010779029 @default.
- W2028994032 hasRelatedWork W2013554741 @default.
- W2028994032 hasRelatedWork W2052580643 @default.
- W2028994032 hasRelatedWork W2142615088 @default.
- W2028994032 hasRelatedWork W2463396694 @default.
- W2028994032 hasRelatedWork W2516833530 @default.
- W2028994032 hasRelatedWork W2528418176 @default.
- W2028994032 hasRelatedWork W2600949589 @default.
- W2028994032 hasRelatedWork W2744531803 @default.
- W2028994032 hasRelatedWork W2748392226 @default.
- W2028994032 hasRelatedWork W2755374832 @default.
- W2028994032 hasRelatedWork W2764015101 @default.
- W2028994032 hasRelatedWork W2804920409 @default.
- W2028994032 hasRelatedWork W2899766571 @default.
- W2028994032 hasRelatedWork W2928714910 @default.
- W2028994032 hasRelatedWork W2955993671 @default.
- W2028994032 hasRelatedWork W2995596755 @default.
- W2028994032 hasRelatedWork W3093130512 @default.
- W2028994032 hasRelatedWork W3118906069 @default.
- W2028994032 isParatext "false" @default.
- W2028994032 isRetracted "false" @default.
- W2028994032 magId "2028994032" @default.
- W2028994032 workType "article" @default.