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• W2028995093 abstract "The leaves of Planchonia careya (F. Muell.) R. Knuth (Lecythidaceae) have been traditionally implemented in the treatment of wounds by the indigenous people of northern Australia, although the compounds responsible for the medicinal properties have not been identified. In this study, antibacterial compounds from the leaf extracts were isolated and characterized, and the biological activity of each compound was assessed. Compounds were isolated from the leaf extracts using HPLC-piloted activity-guided fractionation. The minimum inhibitory concentrations (MICs) were assessed with plate-hole diffusion assays, and the cytotoxicity was determined with MTT assays using monkey kidney epithelial (MA104) cells. Six known compounds were isolated from the leaf extracts and were identified as 1, (+)-gallocatechin; 2, gallocatechin-(4α → 8)-gallocatechin; 3, 9(S)-hydroxy-10E,12Z-octadecadienoic acid (α-dimorphecolic acid); 4, 2α,3β,24-trihydroxyolean-12-en-28-oic acid (hyptatic acid-A); 5, 3β-O-cis-p-coumaroyltormentic acid; and 6, 3β-O-trans-p-coumaroyltormentic acid. Compounds 5 and 6 were weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4 μg/mL and a 50% inhibitory concentration (IC50) of 72.0 μg/mL for MA104 cells. The isolation of six antibacterial compounds from the leaves of Planchonia careya validates the use of this species as a topical wound-healing remedy." @default.
• W2028995093 created "2016-06-24" @default.
• W2028995093 creator A5058552736 @default.
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• W2028995093 date "2008-03-01" @default.
• W2028995093 modified "2023-10-09" @default.
• W2028995093 title "Antibacterial compounds from Planchonia careya leaf extracts" @default.
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• W2028995093 doi "https://doi.org/10.1016/j.jep.2008.01.007" @default.
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