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- W2028996931 endingPage "177" @default.
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- W2028996931 abstract "Summary: The gut epithelial border is in continuous contact with exogenous antigens and harbors a distinctive and very abundant CD8αα intraepithelial T‐lymphocyte effector population. We describe here the characteristics of these cells that distinguish them from all other T‐cell types in the body as well as their functions in local protection. We also describe how these cells differentiate from local precursors present in the gut cryptopatches (CPs) following a pathway of T‐cell differentiation unique to the gut wall. Finally, we describe the origin of the precursors of CD8αα T cells, which come from the bone marrow in athymic mice but are first imprinted in the thymus in euthymic mice. Indeed, CD3 − CD4 − CD8 − T‐cell‐committed precursors can leave the thymus before T‐cell receptor rearrangements and then colonize the gut CPs, proceeding with their differentiation within the gut wall." @default.
- W2028996931 created "2016-06-24" @default.
- W2028996931 creator A5058985066 @default.
- W2028996931 date "2007-02-01" @default.
- W2028996931 modified "2023-10-18" @default.
- W2028996931 title "The extrathymic T-cell differentiation in the murine gut" @default.
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- W2028996931 doi "https://doi.org/10.1111/j.1600-065x.2006.00467.x" @default.
- W2028996931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17291287" @default.
- W2028996931 hasPublicationYear "2007" @default.
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