Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029013019> ?p ?o ?g. }
- W2029013019 endingPage "516" @default.
- W2029013019 startingPage "505" @default.
- W2029013019 abstract "Knowledge of how anthelmintics are metabolized and excreted in nematodes is an integral part of understanding the factors that determine their potency, spectrum of activity and for investigating mechanisms of resistance. Although there is remarkably little information on these processes in nematodes, it is often suggested that they are of minimal importance for the major anthelmintic drugs. Consequently, we have investigated how the model nematode Caenorhabditis elegans responds to and metabolizes albendazole, one of the most important anthelmintic drugs for human and animal use. Using a mutant strain lacking the β-tubulin drug target to minimize generalized stress responses, we show that the transcriptional response is dominated by genes encoding XMEs (xenobiotic-metabolizing enzymes), particularly cytochrome P450s and UGTs (UDP-glucuronosyl transferases). The most highly induced genes are predominantly expressed in the worm intestine, supporting their role in drug metabolism. HPLC-MS/MS revealed the production of two novel glucoside metabolites in C. elegans identifying a major difference in the biotransformation of this drug between nematodes and mammals. This is the first demonstration of metabolism of a therapeutic anthelmintic in C. elegans and provides a framework for its use to functionally investigate nematode anthelmintic metabolism." @default.
- W2029013019 created "2016-06-24" @default.
- W2029013019 creator A5025045104 @default.
- W2029013019 creator A5048335469 @default.
- W2029013019 creator A5048357679 @default.
- W2029013019 creator A5048598584 @default.
- W2029013019 creator A5055755691 @default.
- W2029013019 creator A5058811797 @default.
- W2029013019 creator A5062578335 @default.
- W2029013019 date "2010-11-25" @default.
- W2029013019 modified "2023-10-01" @default.
- W2029013019 title "Characterization of the xenobiotic response of <i>Caenorhabditis elegans</i> to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites" @default.
- W2029013019 cites W118771962 @default.
- W2029013019 cites W1521688557 @default.
- W2029013019 cites W1546760766 @default.
- W2029013019 cites W1583052686 @default.
- W2029013019 cites W1837181068 @default.
- W2029013019 cites W1971693207 @default.
- W2029013019 cites W1980612279 @default.
- W2029013019 cites W1980815463 @default.
- W2029013019 cites W1980920714 @default.
- W2029013019 cites W1981398815 @default.
- W2029013019 cites W1983004272 @default.
- W2029013019 cites W1983599170 @default.
- W2029013019 cites W1987856679 @default.
- W2029013019 cites W1989706787 @default.
- W2029013019 cites W1990770244 @default.
- W2029013019 cites W1991069861 @default.
- W2029013019 cites W1992320741 @default.
- W2029013019 cites W1999616259 @default.
- W2029013019 cites W2004352153 @default.
- W2029013019 cites W2005736771 @default.
- W2029013019 cites W2005831467 @default.
- W2029013019 cites W2005908916 @default.
- W2029013019 cites W2014179603 @default.
- W2029013019 cites W2016235840 @default.
- W2029013019 cites W2021874236 @default.
- W2029013019 cites W2022419534 @default.
- W2029013019 cites W2025089555 @default.
- W2029013019 cites W2035421116 @default.
- W2029013019 cites W2036931975 @default.
- W2029013019 cites W2040454615 @default.
- W2029013019 cites W2043481572 @default.
- W2029013019 cites W2051228079 @default.
- W2029013019 cites W2054582445 @default.
- W2029013019 cites W2055255308 @default.
- W2029013019 cites W2056751633 @default.
- W2029013019 cites W2070055730 @default.
- W2029013019 cites W2073964546 @default.
- W2029013019 cites W2080796517 @default.
- W2029013019 cites W2082776191 @default.
- W2029013019 cites W2083028979 @default.
- W2029013019 cites W2083965229 @default.
- W2029013019 cites W2084738456 @default.
- W2029013019 cites W2088845955 @default.
- W2029013019 cites W2091073857 @default.
- W2029013019 cites W2094663160 @default.
- W2029013019 cites W2095132189 @default.
- W2029013019 cites W2097255766 @default.
- W2029013019 cites W2098086227 @default.
- W2029013019 cites W2098350013 @default.
- W2029013019 cites W2098567793 @default.
- W2029013019 cites W2101058219 @default.
- W2029013019 cites W2109136168 @default.
- W2029013019 cites W2109502717 @default.
- W2029013019 cites W2111483032 @default.
- W2029013019 cites W2119261747 @default.
- W2029013019 cites W2122163057 @default.
- W2029013019 cites W2122548751 @default.
- W2029013019 cites W2122683221 @default.
- W2029013019 cites W2124747558 @default.
- W2029013019 cites W2137016501 @default.
- W2029013019 cites W2139400706 @default.
- W2029013019 cites W2146263980 @default.
- W2029013019 cites W2149085743 @default.
- W2029013019 cites W2158217645 @default.
- W2029013019 cites W2218053556 @default.
- W2029013019 cites W2334509679 @default.
- W2029013019 cites W306302075 @default.
- W2029013019 doi "https://doi.org/10.1042/bj20101346" @default.
- W2029013019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20929438" @default.
- W2029013019 hasPublicationYear "2010" @default.
- W2029013019 type Work @default.
- W2029013019 sameAs 2029013019 @default.
- W2029013019 citedByCount "58" @default.
- W2029013019 countsByYear W20290130192012 @default.
- W2029013019 countsByYear W20290130192013 @default.
- W2029013019 countsByYear W20290130192014 @default.
- W2029013019 countsByYear W20290130192015 @default.
- W2029013019 countsByYear W20290130192016 @default.
- W2029013019 countsByYear W20290130192017 @default.
- W2029013019 countsByYear W20290130192018 @default.
- W2029013019 countsByYear W20290130192019 @default.
- W2029013019 countsByYear W20290130192020 @default.
- W2029013019 countsByYear W20290130192021 @default.
- W2029013019 countsByYear W20290130192022 @default.
- W2029013019 countsByYear W20290130192023 @default.
- W2029013019 crossrefType "journal-article" @default.