FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029014692> ?p ?o ?g. }

• W2029014692 endingPage "253" @default.
• W2029014692 startingPage "252" @default.
• W2029014692 abstract "To the Editor:We read with interest the article by Oakley et al1Oakley GA Muir T Ray M Girdwood RWA Kennedy R Donaldson MDC. Increased incidence of congenital malformations in children with transient thyroid-stimulating hormone elevation on neonatal screening.J Pediatr. 1998; 132: 726-730Abstract Full Text Full Text PDF PubMed Scopus (58) Google Scholar reporting that transient TSH elevation on the fourth day of life is associated with a high incidence of congenital malformations, prematurity, and ìsickness.î A combination of increased perinatal stress and iodine exposure in ill babies may be factors. Their recommendation to reevaluate the thyroid status of those infants at a later date is appropriate indeed.We would like to share our experience with a neonatal screening program for congenital hypothyroidism in which thyroxine and TSH are measured from cord blood (therefore excluding iodine exposure on thyroid function).2Narchi H Kulaylat NA. Congenital hypothyroidism screening program: a five year experience.Ann Saudi Med. 1996; 16: 47-49PubMed Google Scholar In screening 15,000 neonates, 3 cases of primary hypothyroidism were diagnosed (prevalence 1 in 5061 births). Hypothyroxinemia was diagnosed in another 5 who died in the immediate neonatal period; all had congenital malformations, but only 3 had elevated cord TSH (26, 87, and 468 mU/mL). Because all died in the immediate neonatal period, they cannot be classified with certainty as having had transient or permanent hypothyroidism. No postmortem examinations were performed.Although our data support Oakleyís findings that TSH levels are elevated in some neonates with congenital anomalies, this is not invariably the case. Cord blood hypothyroxinemia (regardless of TSH levels) is also associated with congenital anomalies. TSH and T4 were measured before any iodine exposure because none of the affected infants in our series was delivered by cesarean section. Cord blood thyroxine measurement eliminates the potential effect of iodine on the TSH level measured after day 4. To the Editor:We read with interest the article by Oakley et al1Oakley GA Muir T Ray M Girdwood RWA Kennedy R Donaldson MDC. Increased incidence of congenital malformations in children with transient thyroid-stimulating hormone elevation on neonatal screening.J Pediatr. 1998; 132: 726-730Abstract Full Text Full Text PDF PubMed Scopus (58) Google Scholar reporting that transient TSH elevation on the fourth day of life is associated with a high incidence of congenital malformations, prematurity, and ìsickness.î A combination of increased perinatal stress and iodine exposure in ill babies may be factors. Their recommendation to reevaluate the thyroid status of those infants at a later date is appropriate indeed.We would like to share our experience with a neonatal screening program for congenital hypothyroidism in which thyroxine and TSH are measured from cord blood (therefore excluding iodine exposure on thyroid function).2Narchi H Kulaylat NA. Congenital hypothyroidism screening program: a five year experience.Ann Saudi Med. 1996; 16: 47-49PubMed Google Scholar In screening 15,000 neonates, 3 cases of primary hypothyroidism were diagnosed (prevalence 1 in 5061 births). Hypothyroxinemia was diagnosed in another 5 who died in the immediate neonatal period; all had congenital malformations, but only 3 had elevated cord TSH (26, 87, and 468 mU/mL). Because all died in the immediate neonatal period, they cannot be classified with certainty as having had transient or permanent hypothyroidism. No postmortem examinations were performed.Although our data support Oakleyís findings that TSH levels are elevated in some neonates with congenital anomalies, this is not invariably the case. Cord blood hypothyroxinemia (regardless of TSH levels) is also associated with congenital anomalies. TSH and T4 were measured before any iodine exposure because none of the affected infants in our series was delivered by cesarean section. Cord blood thyroxine measurement eliminates the potential effect of iodine on the TSH level measured after day 4. We read with interest the article by Oakley et al1Oakley GA Muir T Ray M Girdwood RWA Kennedy R Donaldson MDC. Increased incidence of congenital malformations in children with transient thyroid-stimulating hormone elevation on neonatal screening.J Pediatr. 1998; 132: 726-730Abstract Full Text Full Text PDF PubMed Scopus (58) Google Scholar reporting that transient TSH elevation on the fourth day of life is associated with a high incidence of congenital malformations, prematurity, and ìsickness.î A combination of increased perinatal stress and iodine exposure in ill babies may be factors. Their recommendation to reevaluate the thyroid status of those infants at a later date is appropriate indeed. We would like to share our experience with a neonatal screening program for congenital hypothyroidism in which thyroxine and TSH are measured from cord blood (therefore excluding iodine exposure on thyroid function).2Narchi H Kulaylat NA. Congenital hypothyroidism screening program: a five year experience.Ann Saudi Med. 1996; 16: 47-49PubMed Google Scholar In screening 15,000 neonates, 3 cases of primary hypothyroidism were diagnosed (prevalence 1 in 5061 births). Hypothyroxinemia was diagnosed in another 5 who died in the immediate neonatal period; all had congenital malformations, but only 3 had elevated cord TSH (26, 87, and 468 mU/mL). Because all died in the immediate neonatal period, they cannot be classified with certainty as having had transient or permanent hypothyroidism. No postmortem examinations were performed. Although our data support Oakleyís findings that TSH levels are elevated in some neonates with congenital anomalies, this is not invariably the case. Cord blood hypothyroxinemia (regardless of TSH levels) is also associated with congenital anomalies. TSH and T4 were measured before any iodine exposure because none of the affected infants in our series was delivered by cesarean section. Cord blood thyroxine measurement eliminates the potential effect of iodine on the TSH level measured after day 4." @default.
• W2029014692 created "2016-06-24" @default.
• W2029014692 creator A5024494429 @default.
• W2029014692 creator A5071869852 @default.
• W2029014692 date "1999-02-01" @default.
• W2029014692 modified "2023-10-13" @default.
• W2029014692 title "Increased TSH levels in neonates with congenital malformations" @default.
• W2029014692 cites W2157525468 @default.
• W2029014692 cites W2416045813 @default.
• W2029014692 doi "https://doi.org/10.1016/s0022-3476(99)70436-1" @default.
• W2029014692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9931551" @default.
• W2029014692 hasPublicationYear "1999" @default.
• W2029014692 type Work @default.
• W2029014692 sameAs 2029014692 @default.
• W2029014692 citedByCount "0" @default.
• W2029014692 crossrefType "journal-article" @default.
• W2029014692 hasAuthorship W2029014692A5024494429 @default.
• W2029014692 hasAuthorship W2029014692A5071869852 @default.
• W2029014692 hasBestOaLocation W20290146921 @default.
• W2029014692 hasConcept C120665830 @default.
• W2029014692 hasConcept C121332964 @default.
• W2029014692 hasConcept C126322002 @default.
• W2029014692 hasConcept C134018914 @default.
• W2029014692 hasConcept C187212893 @default.
• W2029014692 hasConcept C2776169613 @default.
• W2029014692 hasConcept C2777886399 @default.
• W2029014692 hasConcept C2778660577 @default.
• W2029014692 hasConcept C2778840127 @default.
• W2029014692 hasConcept C2779258352 @default.
• W2029014692 hasConcept C2780914630 @default.
• W2029014692 hasConcept C2993291352 @default.
• W2029014692 hasConcept C526584372 @default.
• W2029014692 hasConcept C61511704 @default.
• W2029014692 hasConcept C71924100 @default.
• W2029014692 hasConceptScore W2029014692C120665830 @default.
• W2029014692 hasConceptScore W2029014692C121332964 @default.
• W2029014692 hasConceptScore W2029014692C126322002 @default.
• W2029014692 hasConceptScore W2029014692C134018914 @default.
• W2029014692 hasConceptScore W2029014692C187212893 @default.
• W2029014692 hasConceptScore W2029014692C2776169613 @default.
• W2029014692 hasConceptScore W2029014692C2777886399 @default.
• W2029014692 hasConceptScore W2029014692C2778660577 @default.
• W2029014692 hasConceptScore W2029014692C2778840127 @default.
• W2029014692 hasConceptScore W2029014692C2779258352 @default.
• W2029014692 hasConceptScore W2029014692C2780914630 @default.
• W2029014692 hasConceptScore W2029014692C2993291352 @default.
• W2029014692 hasConceptScore W2029014692C526584372 @default.
• W2029014692 hasConceptScore W2029014692C61511704 @default.
• W2029014692 hasConceptScore W2029014692C71924100 @default.
• W2029014692 hasIssue "2" @default.
• W2029014692 hasLocation W20290146921 @default.
• W2029014692 hasLocation W20290146922 @default.
• W2029014692 hasOpenAccess W2029014692 @default.
• W2029014692 hasPrimaryLocation W20290146921 @default.
• W2029014692 hasRelatedWork W2029814448 @default.
• W2029014692 hasRelatedWork W2033031887 @default.
• W2029014692 hasRelatedWork W2057432389 @default.
• W2029014692 hasRelatedWork W2102878215 @default.
• W2029014692 hasRelatedWork W2339771249 @default.
• W2029014692 hasRelatedWork W2481635608 @default.
• W2029014692 hasRelatedWork W2531615729 @default.
• W2029014692 hasRelatedWork W3004942675 @default.
• W2029014692 hasRelatedWork W4281975634 @default.
• W2029014692 hasRelatedWork W4286493402 @default.
• W2029014692 hasVolume "134" @default.
• W2029014692 isParatext "false" @default.
• W2029014692 isRetracted "false" @default.
• W2029014692 magId "2029014692" @default.
• W2029014692 workType "article" @default.