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- W2029017656 abstract "Aims: Patients with gastric cancer (GC) have a poor survival and biologicals such as Trastuzumab have not been used routinely in these patients. Studies in breast cancer indicate that response to Trastuzumab depends on membranous HER2 overexpression or HER2 amplification. Existing data on the clinical relevance of HER2 expression in GC are still limited and controversial. Methods: HER2 expression was investigated by immunohistochemistry using full sections from 418 GC from Germany (series A) and tissue microarrays constructed from 506 GC from England (series B). The 'DAKO score' and a continuous percentage scale were used for scoring. Results were compared to clinicopathological parameters and patient survival. Results: HER2 expression showed prominent intratumoural heterogeneity. Using a 5% cut off, 6% (n=57) of all GC were classified HER2 positive and 91% of these were intestinal type GC. In both series, no relationship was found between HER2 expression, patient survival or TNM stage. Conclusions: This is the largest study todate confirming in two independent GC series that HER2 expression is not related to patient prognosis. Our results indicate that only a very small subgroup of intestinal type GC may potentially respond to Trastuzumab. In contrast to breast cancer, prominent heterogeneity of HER2 expression in GC tissue was observed which will make pre-treatment HER2 testing of endoscopic biopsies challenging due to the potentially high number of false negative results." @default.
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- W2029017656 date "2009-10-01" @default.
- W2029017656 modified "2023-10-18" @default.
- W2029017656 title "HER2neu-Expression beim Magenkarzinom: selten, heterogen und ohne prognostische Bedeutung – Eine immunhistologische Untersuchung an 924 Fällen zweier unabhängiger Tumorserien" @default.
- W2029017656 doi "https://doi.org/10.1055/s-0029-1242230" @default.
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