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• W2029018032 endingPage "33" @default.
• W2029018032 startingPage "19" @default.
• W2029018032 abstract "Although endometrial cancer is the most common female malignancy, evidence-based uniform guidelines for postoperative therapy have not been established. The most logical management is adjuvant irradiation tailored to the extent of surgery, the tumour grade, depth of myometrial invasion, degree of lymph node involvement and age of the patient. Currently, the only widely accepted treatment recommendations are no further therapy in low-risk patients who underwent extensive surgical staging, and external beam radiotherapy (EBRT) in high-risk patients. Most authors recommend postoperative application of only one radiotherapy modality: either brachytherapy (BRT) or EBRT, as their routine combination does not clearly improve the outcome but does increase the risk of late complications. A combination of BRT and EBRT should however be considered in patients with stage II disease, for infiltration of the lower uterine segment, vaginal involvement, positive or close surgical margins, capillary space involvement or unfavourable histology. Two recent randomized studies including mostly intermediate-risk patients managed with either extensive surgical staging or total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH&BSO) with or without postoperative EBRT, showed better local control but no survival benefit from adjuvant irradiation. Two ongoing Gynecologic Oncology Group (GOG) studies compare adjuvant chemotherapy with pelvic or abdominal irradiation in patients with high risk of local relapse. The role of adjuvant radiotherapy (EBRT with or without BRT) in high-risk patients as well as the value of lymphadenectomy in patients fit for such surgery is being addressed in a trial co-ordinated by the Medical Research Council. Future studies are warranted to define whether any irradiation should be employed in intermediate-risk patients and which radiotherapy modality should be used in high-risk node-negative patients with stage I tumours (stage Ib grade 3 and all stage Ic). Other issues which should be addressed in future studies include the extent of surgery, the role of systemic therapies, the relevance of novel biologic prognostic factors, salvage therapies after recurrence, cost-benefit analysis and quality of life." @default.
• W2029018032 created "2016-06-24" @default.
• W2029018032 creator A5088168853 @default.
• W2029018032 date "2001-02-01" @default.
• W2029018032 modified "2023-10-14" @default.
• W2029018032 title "Postoperative irradiation in endometrial cancer: still a matter of controversy" @default.
• W2029018032 cites W1509960021 @default.
• W2029018032 cites W1639623707 @default.
• W2029018032 cites W1665347644 @default.
• W2029018032 cites W1843698095 @default.
• W2029018032 cites W1966702850 @default.
• W2029018032 cites W1968199167 @default.
• W2029018032 cites W1968253256 @default.
• W2029018032 cites W1968829505 @default.
• W2029018032 cites W1972450145 @default.
• W2029018032 cites W1972459258 @default.
• W2029018032 cites W1974023896 @default.
• W2029018032 cites W1975295198 @default.
• W2029018032 cites W1975440192 @default.
• W2029018032 cites W1975754022 @default.
• W2029018032 cites W1976641568 @default.
• W2029018032 cites W1978184587 @default.
• W2029018032 cites W1979025468 @default.
• W2029018032 cites W1980551630 @default.
• W2029018032 cites W1980606545 @default.
• W2029018032 cites W1980745607 @default.
• W2029018032 cites W1980840729 @default.
• W2029018032 cites W1981937277 @default.
• W2029018032 cites W1983052203 @default.
• W2029018032 cites W1983696584 @default.
• W2029018032 cites W1985655921 @default.
• W2029018032 cites W1985981032 @default.
• W2029018032 cites W1986916813 @default.
• W2029018032 cites W1988855646 @default.
• W2029018032 cites W1990074472 @default.
• W2029018032 cites W1990306613 @default.
• W2029018032 cites W1992321249 @default.
• W2029018032 cites W1992374093 @default.
• W2029018032 cites W1992973264 @default.
• W2029018032 cites W1994601570 @default.
• W2029018032 cites W1995318474 @default.
• W2029018032 cites W1995806028 @default.
• W2029018032 cites W1998014083 @default.
• W2029018032 cites W1999037811 @default.
• W2029018032 cites W1999089268 @default.
• W2029018032 cites W2000828175 @default.
• W2029018032 cites W2002006344 @default.
• W2029018032 cites W2002612094 @default.
• W2029018032 cites W2003038632 @default.
• W2029018032 cites W2003502681 @default.
• W2029018032 cites W2004135660 @default.
• W2029018032 cites W2007160797 @default.
• W2029018032 cites W2008118429 @default.
• W2029018032 cites W2011363925 @default.
• W2029018032 cites W2011433482 @default.
• W2029018032 cites W2012529498 @default.
• W2029018032 cites W2013000212 @default.
• W2029018032 cites W2014996059 @default.
• W2029018032 cites W2016222118 @default.
• W2029018032 cites W2016421629 @default.
• W2029018032 cites W2016558284 @default.
• W2029018032 cites W2020378886 @default.
• W2029018032 cites W2021159519 @default.
• W2029018032 cites W2022335561 @default.
• W2029018032 cites W2022775755 @default.
• W2029018032 cites W2024469204 @default.
• W2029018032 cites W2026020827 @default.
• W2029018032 cites W2026778368 @default.
• W2029018032 cites W2028921657 @default.
• W2029018032 cites W2029292517 @default.
• W2029018032 cites W2030024719 @default.
• W2029018032 cites W2032503180 @default.
• W2029018032 cites W2032768962 @default.
• W2029018032 cites W2032997711 @default.
• W2029018032 cites W2034008065 @default.
• W2029018032 cites W2035269440 @default.
• W2029018032 cites W2035663835 @default.
• W2029018032 cites W2035971251 @default.
• W2029018032 cites W2036913860 @default.
• W2029018032 cites W2040246100 @default.
• W2029018032 cites W2040778854 @default.
• W2029018032 cites W2040810255 @default.
• W2029018032 cites W2041094935 @default.
• W2029018032 cites W2041785837 @default.
• W2029018032 cites W2043330112 @default.
• W2029018032 cites W2043687307 @default.
• W2029018032 cites W2044217347 @default.
• W2029018032 cites W2046456934 @default.
• W2029018032 cites W2046569169 @default.
• W2029018032 cites W2048925009 @default.
• W2029018032 cites W2049501242 @default.
• W2029018032 cites W2050596640 @default.
• W2029018032 cites W2053894234 @default.
• W2029018032 cites W2056935976 @default.
• W2029018032 cites W2058199823 @default.
• W2029018032 cites W2059286344 @default.
• W2029018032 cites W2061182359 @default.
• W2029018032 cites W2061420655 @default.

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