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• W2029033280 abstract "Members of the protein kinase C (PKC) family play important but distinct roles in B-cell activation, as demonstrated by emerging genetic and biochemical studies. PKCbeta is indispensable for B-cell antigen receptor (BCR)-induced NF-kappaB activation and B-cell survival. Recent evidence indicates that PKCbeta might regulate inhibitor of kappaB kinase (IKK) and NF-kappaB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains. By contrast, the novel PKC isoform PKCdelta is specifically required to maintain the tolerance of self-reactive B cells." @default.
• W2029033280 created "2016-06-24" @default.
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• W2029033280 date "2004-06-01" @default.
• W2029033280 modified "2023-09-25" @default.
• W2029033280 title "Protein kinase C family functions in B-cell activation" @default.
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• W2029033280 doi "https://doi.org/10.1016/j.coi.2004.03.012" @default.
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