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- W2029036100 abstract "The objective of this study on guinea-pig and rabbit ventricular myocytes was to evaluate the sensitivities of swelling-activated Cl− current (ICl(swell)) and cAMP-dependent cystic fibrosis transmembrane regulator (CFTR) Cl− current (ICl(CFTR)) to block by dideoxyforskolin and verapamil. The currents were recorded from whole-cell configured myocytes that were dialysed with a Cs+-rich pipette solution and superfused with either isosmotic Na+-, K+-, Ca2+-free solution that contained 140 mM sucrose or hyposmotic sucrose-free solution. Forskolin-activated ICl(CFTR) was inhibited by reference blocker anthracene-9-carboxylic acid but unaffected by ≤200 μM dideoxyforskolin and verapamil. However, dideoxyforskolin and verapamil had strong inhibitory effects on outwardly-rectifying, inactivating, distilbene-sensitive ICl(swell); IC50 values were ≈30 μM, and blocks were voltage-independent and reversible. The results establish that dideoxyforskolin and verapamil can be used to distinguish between ICl(CFTR) and ICl(swell) in heart cells, and expand the pharmacological characterization of cardiac ICl(swell)." @default.
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- W2029036100 date "2004-05-01" @default.
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- W2029036100 title "Selective block of swelling-activated Cl− channels over cAMP-dependent Cl− channels in ventricular myocytes" @default.
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- W2029036100 doi "https://doi.org/10.1016/j.ejphar.2004.03.036" @default.
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