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• W2029036246 endingPage "566" @default.
• W2029036246 startingPage "561" @default.
• W2029036246 abstract "Abstract Relative proportions of peripheral blood (PB) B lymphocytes (B220%) as well as CD4 (CD4%) and CD8 (CD8%) T lymphocytes differ significantly among inbred mouse strains: B220% is high in C57BL/6J (B6) and C57BR/cdJ, intermediate in BALB/cByJ (BALB) and DBA/2J (D2), and low in NOD/LtJ (NOD) and SJL/J (SJL) mice, whereas CD4% and CD8% are high in NOD and SJL mice and low in the other 4 strains. By following segregating genetic markers linked to these traits in (B6 × D2) recombinant inbred (BXD RI) mice, the study defined 2 quantitative trait loci (QTLs) for the B220% phenotype:Pbbcp1 (peripheral blood B cell percentage 1, logarithm of odds [LOD] 4.1, P &lt; .000 01) and Pbbcp2(LOD 3.7, P &lt; .000 04) on chromosome 1 (Chr 1) at about 63 cM and 48 cM; one suggestive locus for the CD4% phenotype (LOD 2.6,P &lt; .000 57) on Chr 8 at about 73 cM; and one QTL for the CD8% phenotype: Pbctlp1 (peripheral blood cytotoxic T lymphocyte percentage 1, LOD 3.8, P &lt; .000 02) on Chr 19 at about 12 cM. The study further segregated PB lymphocyte proportions in B6SJLF2 mice by using DNA markers adjacent to these mapped QTLs and found that the Pbbcp1 locus (LOD 5.6,P &lt; .000 01) was also important in this mouse population. In both BXD RI and B6SJLF2 mice, QTLs regulating B-cell proportions showed no significant effect on T-cell proportions and vice versa. Thus, PB B- and T-lymphocyte proportions are regulated separately by different genetic elements." @default.
• W2029036246 created "2016-06-24" @default.
• W2029036246 creator A5050700780 @default.
• W2029036246 creator A5084162691 @default.
• W2029036246 date "2002-01-15" @default.
• W2029036246 modified "2023-10-18" @default.
• W2029036246 title "Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood" @default.
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• W2029036246 doi "https://doi.org/10.1182/blood.v99.2.561" @default.
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