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• W2029039230 startingPage "3503" @default.
• W2029039230 abstract "Articles in recent years have described two separate and distinct NF-kappaB activation pathways that result in the differential activation of p50- or p52-containing NF-kappaB complexes. Studies examining tumor-necrosis factor receptor-associated factors (TRAFs) have identified positive roles for TRAF2, TRAF5, and TRAF6, but not TRAF3, in canonical (p50-dependent) NF-kappaB activation. Conversely, it recently was reported that TRAF3 functions as an essential negative regulator of the noncanonical (p52-dependent) NF-kappaB pathway. In this article, we provide evidence that TRAF3 potently suppresses canonical NF-kappaB activation and gene expression in vitro and in vivo. We also demonstrate that deregulation of the canonical NF-kappaB pathway in TRAF3-deficient cells results from accumulation of NF-kappaB-inducing kinase (NIK), the essential kinase mediating noncanonical NF-kappaB activation. Thus, our data demonstrate that inhibition of TRAF3 results in coordinated activation of both NF-kappaB activation pathways." @default.
• W2029039230 created "2016-06-24" @default.
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• W2029039230 creator A5091163836 @default.
• W2029039230 date "2008-03-04" @default.
• W2029039230 modified "2023-10-13" @default.
• W2029039230 title "Control of canonical NF-κB activation through the NIK–IKK complex pathway" @default.
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• W2029039230 doi "https://doi.org/10.1073/pnas.0707959105" @default.
• W2029039230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2265190" @default.
• W2029039230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18292232" @default.
• W2029039230 hasPublicationYear "2008" @default.
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