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• W2029043572 abstract "Abstract Two representative phyto-estrogens, coumestrol (Co) and genistein (G) were studied with respect to their estrogenic and antiestrogenic action. A preliminary trial involving the feeding of estradiol-17β (E 2 ), G and alfalfa (estrogenic) for one week to immature rats indicated that G increased the number of E 2 cytosol binding sites/g uterus. The results of the alfalfa feeding were similar to that of G but not as defined. To study further the effects of G and Co on receptor parameters, additional measurements of cytosol and nuclear bindings were determined following single subcutaneous injections of E 2 , G, Co and clomiphene (CI) and estriol (E 3 ). Total cytosol receptor concentrations were measured by Scatchard analysis. Both G and Co injections resulted in an initial partial depletion of sites followed in 25 h by recovery to control levels less than the replenishment after the injection of E 2 and unlike the effects of CI, which caused a more prolonged depletion of sites. A second reduction of cytoplasmic sites following injection of G and Co occurred at 40 h. The number of estrogen receptor sites translocated to the nucleus was measured by nuclear exchange assay and significant translocation had occurred by 2 h after injection, explaining the initial decrease in cytoplasmic sites. The retention of Co in the nucleus was less prolonged than that of E 2 and more similar to E 3 . The cause of the 40 h depletion of cytoplasmic sites following Co and G injection is not clear. This evidence suggests that Co and G behave as weak estrogens in a manner similar to that reported for E 3 or dimethylstilbestrol. Their antiestrogenic effects are probably related to the incompleteness of replenishment as compared to effects of E 2 , and are not the result of prolonged initial depletion of cytoplasmic sites nor prolonged retention in the nucleus as is the case with CI. The doses of phyto-estrogens used throughout this study were in amounts 60 to 400 times more than that of the physiological dose of E 2 (e.g., subcutaneous injection of 0.125 μg E 2 /rat). As the phyto-estrogenic concentration in the blood of farm animals consuming estrogenic forages, such as alfalfa or clover species can be 100 times more than that of the circulating E 2 , these results relate to the problem of reproductive disorders in animals resulting from the consumption of estrogenic forages." @default.
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• W2029043572 date "1980-09-01" @default.
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• W2029043572 title "Action of phyto-estrogens coumestrol and genistein on cytosolic and nuclear oestradiol-17β receptors in immature rat uterus" @default.
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