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- W2029043968 abstract "The cytoplasmic Na+ concentration ([Na+]i) was measured in individual mouse beta-cells and islet cell aggregates using the indicator SBFI. Small oscillations of [Na+]i were occasionally observed after raising glucose from 3 to 11 mM. Distinct oscillations with a frequency of 0.29 +/- 0.02 min-1 (n = 18) and amplitudes of 7.4 +/- 0.5 mM (n = 18) were obtained when also adding the Na+ channel agonist veratridine. The oscillations were counteracted by tetrodotoxin or by lowering the glucose concentration to 3 mM. Glucose failed to induce oscillations when increasing Na+ entry by co-transport with L-glycine or raising [Na+]i by blocking the Na/K pump with ouabain. The results indicate that glucose can induce oscillations of [Na+]i in pancreatic beta-cells, although this effect is usually less obvious due to activation of an efficient Na/K pump." @default.
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- W2029043968 title "Glucose Induces Cytoplasmic Na+Oscillations in Pancreatic β-Cells" @default.
- W2029043968 doi "https://doi.org/10.1006/bbrc.1996.1436" @default.
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