FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029046001> ?p ?o ?g. }

• W2029046001 endingPage "5375" @default.
• W2029046001 startingPage "5368" @default.
• W2029046001 abstract "ABSTRACT The control of intracellular pathogens such as Mycobacterium tuberculosis is dependent on the activation and maintenance of pathogen-reactive T cells. Dendritic cells (DCs) are the major antigen-presenting cells initiating antimycobacterial T-cell responses in vivo. To investigate if immunization strategies that aim to optimize DC function can improve protective immunity against virulent mycobacterial infection, we exploited the ability of the hematopoietic growth factor Fms-like tyrosine kinase 3 ligand (Flt3L) to expand the number of DCs in vivo. A DNA fusion of the genes encoding murine Flt3L and M. tuberculosis antigen 85B stimulated enhanced gamma interferon (IFN-γ) release by T cells and provided better protection against virulent M. tuberculosis than DNA encoding the single components. Vaccination of mice with a recombinant Mycobacterium bovis BCG strain secreting Flt3L (BCG:Flt3L) led to early expansion of DCs compared to immunization with BCG alone, and this effect was associated with increased stimulation of BCG-reactive IFN-γ-secreting T cells. BCG and BCG:Flt3L provided similar protective efficacies against low-dose aerosol M. tuberculosis ; however, immunization of immunodeficient mice revealed that BCG:Flt3L was markedly less virulent than conventional BCG. These results demonstrate the potential of in vivo targeting of DCs to improve antimycobacterial vaccine efficacy." @default.
• W2029046001 created "2016-06-24" @default.
• W2029046001 creator A5025122365 @default.
• W2029046001 creator A5030481213 @default.
• W2029046001 creator A5036392459 @default.
• W2029046001 creator A5037395365 @default.
• W2029046001 creator A5063791776 @default.
• W2029046001 creator A5072746292 @default.
• W2029046001 creator A5085549134 @default.
• W2029046001 date "2007-11-01" @default.
• W2029046001 modified "2023-10-18" @default.
• W2029046001 title "Effects of DNA- and <i>Mycobacterium bovis</i> BCG-Based Delivery of the Flt3 Ligand on Protective Immunity to <i>Mycobacterium tuberculosis</i>" @default.
• W2029046001 cites W1554027982 @default.
• W2029046001 cites W1573172534 @default.
• W2029046001 cites W1576095056 @default.
• W2029046001 cites W1683960100 @default.
• W2029046001 cites W1858218633 @default.
• W2029046001 cites W1895622651 @default.
• W2029046001 cites W1898098760 @default.
• W2029046001 cites W1905061145 @default.
• W2029046001 cites W1971661340 @default.
• W2029046001 cites W1990159457 @default.
• W2029046001 cites W1991661470 @default.
• W2029046001 cites W1992694561 @default.
• W2029046001 cites W2003084960 @default.
• W2029046001 cites W2015266578 @default.
• W2029046001 cites W2016042447 @default.
• W2029046001 cites W2049675690 @default.
• W2029046001 cites W2053655431 @default.
• W2029046001 cites W2054123743 @default.
• W2029046001 cites W2056648197 @default.
• W2029046001 cites W2062495971 @default.
• W2029046001 cites W2064809491 @default.
• W2029046001 cites W2093423705 @default.
• W2029046001 cites W2094043105 @default.
• W2029046001 cites W2115663485 @default.
• W2029046001 cites W2118508196 @default.
• W2029046001 cites W2119407824 @default.
• W2029046001 cites W2120652044 @default.
• W2029046001 cites W2135254713 @default.
• W2029046001 cites W2135674359 @default.
• W2029046001 cites W2136501069 @default.
• W2029046001 cites W2140767223 @default.
• W2029046001 cites W2149737058 @default.
• W2029046001 cites W2154218327 @default.
• W2029046001 cites W2155268643 @default.
• W2029046001 cites W2156831625 @default.
• W2029046001 cites W2157559696 @default.
• W2029046001 cites W2165508954 @default.
• W2029046001 cites W2170240282 @default.
• W2029046001 cites W2171231066 @default.
• W2029046001 cites W2325666068 @default.
• W2029046001 cites W3022052369 @default.
• W2029046001 doi "https://doi.org/10.1128/iai.00322-07" @default.
• W2029046001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2168302" @default.
• W2029046001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17724075" @default.
• W2029046001 hasPublicationYear "2007" @default.
• W2029046001 type Work @default.
• W2029046001 sameAs 2029046001 @default.
• W2029046001 citedByCount "30" @default.
• W2029046001 countsByYear W20290460012012 @default.
• W2029046001 countsByYear W20290460012014 @default.
• W2029046001 countsByYear W20290460012016 @default.
• W2029046001 countsByYear W20290460012017 @default.
• W2029046001 countsByYear W20290460012019 @default.
• W2029046001 countsByYear W20290460012020 @default.
• W2029046001 countsByYear W20290460012021 @default.
• W2029046001 countsByYear W20290460012022 @default.
• W2029046001 countsByYear W20290460012023 @default.
• W2029046001 crossrefType "journal-article" @default.
• W2029046001 hasAuthorship W2029046001A5025122365 @default.
• W2029046001 hasAuthorship W2029046001A5030481213 @default.
• W2029046001 hasAuthorship W2029046001A5036392459 @default.
• W2029046001 hasAuthorship W2029046001A5037395365 @default.
• W2029046001 hasAuthorship W2029046001A5063791776 @default.
• W2029046001 hasAuthorship W2029046001A5072746292 @default.
• W2029046001 hasAuthorship W2029046001A5085549134 @default.
• W2029046001 hasBestOaLocation W20290460011 @default.
• W2029046001 hasConcept C142724271 @default.
• W2029046001 hasConcept C147483822 @default.
• W2029046001 hasConcept C159047783 @default.
• W2029046001 hasConcept C167508917 @default.
• W2029046001 hasConcept C203014093 @default.
• W2029046001 hasConcept C22070199 @default.
• W2029046001 hasConcept C2777975735 @default.
• W2029046001 hasConcept C2778288313 @default.
• W2029046001 hasConcept C2778497218 @default.
• W2029046001 hasConcept C2779078216 @default.
• W2029046001 hasConcept C2780801004 @default.
• W2029046001 hasConcept C2781069245 @default.
• W2029046001 hasConcept C71924100 @default.
• W2029046001 hasConcept C86803240 @default.
• W2029046001 hasConcept C8891405 @default.
• W2029046001 hasConcept C89423630 @default.
• W2029046001 hasConceptScore W2029046001C142724271 @default.
• W2029046001 hasConceptScore W2029046001C147483822 @default.
• W2029046001 hasConceptScore W2029046001C159047783 @default.
• W2029046001 hasConceptScore W2029046001C167508917 @default.

• next