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- W2029049922 abstract "Peripheral vascular diseases such as diabetic microcirculatory disorders, Raynaud’s syndrome and chronic leg ulcers are known to be associated with impaired endothelial nitric oxide (NO) production. Therefore, formulations capable of releasing NO topically through the skin, may offer a new approach for treating these diseases. In the present work, we have shown that topical S-nitrosothiol (RSNOs)-containing hydrogel formulations are capable of releasing free NO gas through the skin of health human volunteers, leading to dermal vasodilation, measured with laser Doppler flowmetry. RSNOs concentrations ranging from 50 to 150 mM led to a dose response increase in the local blood flow with rates varying from 0.7 to 1.7 × 10−3 AU s−1 in a 10 min period, and to vasodilation plateaus maintained for more than 4 h in single applications. The rates of NO release of the formulations were measured using a modified Franz-type diffusion cell coupled to a chemiluminescence NO analyser with a NO-permeable polypropylene membrane, confirming that the formulations release NO thermally and showing that the NO release rate may be greatly increased by irradiation with visible light. These findings show that these formulations may offer an effective and controlled way for delivering NO gas locally for treating ischemic tissues or ulcers." @default.
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- W2029049922 date "2012-07-01" @default.
- W2029049922 modified "2023-10-02" @default.
- W2029049922 title "Topical vasodilator hydrogels for transdermal release of gaseous NO" @default.
- W2029049922 doi "https://doi.org/10.1016/j.niox.2012.04.120" @default.
- W2029049922 hasPublicationYear "2012" @default.
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