FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029062208> ?p ?o ?g. }

• W2029062208 endingPage "566" @default.
• W2029062208 startingPage "562" @default.
• W2029062208 abstract "DAS181 is a novel drug in development for the treatment of influenza as well as human parainfluenza viruses (hPIVs). Previous studies demonstrated that DAS181 inhibited laboratory strains of hPIV, but no tests were conducted with primary clinical isolates of hPIV. To fill this gap, we studied six primary isolates including hPIV-2 and hPIV-3. First tests showed that the amplification of all viruses in vitro was reproducibly inhibited with DAS181 drug concentrations ranging between 0.1 and 1 nM. An hPIV-3 primary clinical isolate was then tested in a cotton rat model for sensitivity to 0.3–1 mg/kg drug treatments. Results showed that virus amplification in the lower respiratory tract was significantly and reproducibly inhibited by drug. Together, experiments demonstrated that DAS181 inhibited primary clinical isolates of hPIV in vitro and in vivo at doses similar to those previously described for inhibition of laboratory hPIV and influenza virus isolates." @default.
• W2029062208 created "2016-06-24" @default.
• W2029062208 creator A5019333356 @default.
• W2029062208 creator A5044380425 @default.
• W2029062208 creator A5051793462 @default.
• W2029062208 date "2013-11-01" @default.
• W2029062208 modified "2023-09-26" @default.
• W2029062208 title "Inhibition of primary clinical isolates of human parainfluenza virus by DAS181 in cell culture and in a cotton rat model" @default.
• W2029062208 cites W131247432 @default.
• W2029062208 cites W1587234115 @default.
• W2029062208 cites W1787921311 @default.
• W2029062208 cites W1981257082 @default.
• W2029062208 cites W1984343838 @default.
• W2029062208 cites W1995202219 @default.
• W2029062208 cites W1996436367 @default.
• W2029062208 cites W2002974329 @default.
• W2029062208 cites W2004915008 @default.
• W2029062208 cites W2025455407 @default.
• W2029062208 cites W2026499179 @default.
• W2029062208 cites W2027638537 @default.
• W2029062208 cites W2028447562 @default.
• W2029062208 cites W2033997527 @default.
• W2029062208 cites W2038634991 @default.
• W2029062208 cites W2045972097 @default.
• W2029062208 cites W2046113457 @default.
• W2029062208 cites W2046662624 @default.
• W2029062208 cites W2046737200 @default.
• W2029062208 cites W2055735404 @default.
• W2029062208 cites W2056574647 @default.
• W2029062208 cites W2065173827 @default.
• W2029062208 cites W2066296226 @default.
• W2029062208 cites W2071929059 @default.
• W2029062208 cites W2072358966 @default.
• W2029062208 cites W2087810619 @default.
• W2029062208 cites W2096917554 @default.
• W2029062208 cites W2112927579 @default.
• W2029062208 cites W2116432774 @default.
• W2029062208 cites W2120686123 @default.
• W2029062208 cites W2121777137 @default.
• W2029062208 cites W2133718742 @default.
• W2029062208 cites W2147735785 @default.
• W2029062208 cites W2149305405 @default.
• W2029062208 cites W2154292852 @default.
• W2029062208 cites W2159953474 @default.
• W2029062208 cites W2316631733 @default.
• W2029062208 cites W2322654587 @default.
• W2029062208 cites W2331031405 @default.
• W2029062208 cites W4211221339 @default.
• W2029062208 doi "https://doi.org/10.1016/j.antiviral.2013.09.014" @default.
• W2029062208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3871174" @default.
• W2029062208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24076357" @default.
• W2029062208 hasPublicationYear "2013" @default.
• W2029062208 type Work @default.
• W2029062208 sameAs 2029062208 @default.
• W2029062208 citedByCount "9" @default.
• W2029062208 countsByYear W20290622082014 @default.
• W2029062208 countsByYear W20290622082016 @default.
• W2029062208 countsByYear W20290622082019 @default.
• W2029062208 countsByYear W20290622082020 @default.
• W2029062208 crossrefType "journal-article" @default.
• W2029062208 hasAuthorship W2029062208A5019333356 @default.
• W2029062208 hasAuthorship W2029062208A5044380425 @default.
• W2029062208 hasAuthorship W2029062208A5051793462 @default.
• W2029062208 hasBestOaLocation W20290622082 @default.
• W2029062208 hasConcept C105702510 @default.
• W2029062208 hasConcept C150903083 @default.
• W2029062208 hasConcept C159047783 @default.
• W2029062208 hasConcept C202751555 @default.
• W2029062208 hasConcept C207001950 @default.
• W2029062208 hasConcept C2522874641 @default.
• W2029062208 hasConcept C2779644171 @default.
• W2029062208 hasConcept C2780035454 @default.
• W2029062208 hasConcept C2910309107 @default.
• W2029062208 hasConcept C534529494 @default.
• W2029062208 hasConcept C55493867 @default.
• W2029062208 hasConcept C86803240 @default.
• W2029062208 hasConcept C89423630 @default.
• W2029062208 hasConcept C98274493 @default.
• W2029062208 hasConceptScore W2029062208C105702510 @default.
• W2029062208 hasConceptScore W2029062208C150903083 @default.
• W2029062208 hasConceptScore W2029062208C159047783 @default.
• W2029062208 hasConceptScore W2029062208C202751555 @default.
• W2029062208 hasConceptScore W2029062208C207001950 @default.
• W2029062208 hasConceptScore W2029062208C2522874641 @default.
• W2029062208 hasConceptScore W2029062208C2779644171 @default.
• W2029062208 hasConceptScore W2029062208C2780035454 @default.
• W2029062208 hasConceptScore W2029062208C2910309107 @default.
• W2029062208 hasConceptScore W2029062208C534529494 @default.
• W2029062208 hasConceptScore W2029062208C55493867 @default.
• W2029062208 hasConceptScore W2029062208C86803240 @default.
• W2029062208 hasConceptScore W2029062208C89423630 @default.
• W2029062208 hasConceptScore W2029062208C98274493 @default.
• W2029062208 hasFunder F4320313598 @default.
• W2029062208 hasFunder F4320337355 @default.
• W2029062208 hasIssue "2" @default.
• W2029062208 hasLocation W20290622081 @default.
• W2029062208 hasLocation W20290622082 @default.
• W2029062208 hasLocation W20290622083 @default.

• next