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- W2029062783 abstract "56 Growth of mature allografts is a critical issue in pediatric lung transplantation. This study explores the architectural changes of mature sheep lung when submitted to two different compensatory growth forces; either transplantation into a neonatal host or expansion in an otherwise empty adult hemithorax. Right upper lobes (RUL) from adult sheep (mean ± sem) 66.7 ± 1.9 kg, 4 to 5 years old were transplanted into newborn (n=6) lambs 5.4 ± 0.3 kg, 5 ± 2 days old and were allowed to survive for 45 days. Changes in pulmonary volume and architecture were measured before and after transplantation. Allografts were compared with both normal adult RUL (n=10) and adult (65.8 ± 2.2kg and 4 to 5 years old) RUL that remained in situ for 45 days after resection of the corresponding middle and lower lobes (n=6). Statistical differences were analyzed using two sample and paired t-tests. In adult animals, RUL remaining in the otherwise empty hemithorax compensated by an 85% increase in volume (252 ± 19cc vs 466 ± 33cc) (p<0.0001). Concomitant increases in total internal alveolar surface area (48%) and alveolar size were prominent. The number of alveoli per volume decreased proportionately to the increases in volume (p<0.0001). There was no significant change in the calculated number of alveoli (345 ± 40 × 106) compared to the normal adult RUL (402 ± 41 × 106) (p=0.37). Transplant recipients received a reduced-sized normal adult RUL (49% in volume, 125 ± 21cc). Allografts 45 days after transplantation showed a 73% increase in volume (216 ± 21cc) (p<0.0001) with a parallel 83% increase in total internal alveolar surface area (p=0.008). The number of alveoli per volume remained constant (p=0.21) despite the increase in volume. There was therefore a significant increase in the calculated number of alveoli from pretransplant (172 ± 36 × 106) compared to that observed 45 days post-transplantation (390 ± 78 × 106) (p=0.012). We conclude that mature sheep RUL parenchyma compensates with dilatation of the respiratory structures in the adult animal whereas there is alveolar multiplication when transplanted into newborn recipients." @default.
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- W2029062783 date "1998-10-01" @default.
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- W2029062783 title "LUNG GROWTH FOLLOWING REDUCED-SIZED LUNG TRANSPLANTATION IN A SHEEP MODEL" @default.
- W2029062783 doi "https://doi.org/10.1097/00007890-199810270-00086" @default.
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