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• W2029071731 endingPage "152" @default.
• W2029071731 startingPage "141" @default.
• W2029071731 abstract "Aminoadamantane derivatives (AAD) such as amantadine or memantine have been used for the treatment of Morbus Parkinson and Morbus Alzheimer. In this communication, we report on the immunomodulatory activities of AAD. Luminol-dependent chemiluminescence of zymosan-, N-formylmethionylleucylphenylalanine(FMLP)- or experimental Ca2+-ionophore(A 231879)-preactivated polymorphonuclear leukocytes (PMN) was strongly enhanced by submicromolar concentrations of AAD and inhibited at higher concentrations than 0.1 mM. Light emission by phorbol-12-myristate-acetate(PMA)-preactivated cells was not further stimulated but inhibited by the elevated concentrations, just as with the other, above-mentioned activators. Ethylene formation from alpha-keto-methylthiobutyrate (KMB) as an indicator for production of OH.-type reactive oxygen species by the NADPH-oxidase (respiratory burst) was augmented by AAD and completely inhibited by superoxide dismutase. In contrast, ethylene release from 1-amino-cyclopropyl-l-carboxylic acid (ACC) as relatively specific indicator for the myeloperoxidase reaction after degranulation was not influenced by AAD. As documented by several model reactions, AAD per se did not act as scavengers or quenchers of activated oxygen species such as superoxide, OH.-radical, hydrogen peroxide or hypochlorite. Altogether, these results suggest that submicromolar concentrations of AAD upregulate the respiratory burst, but apparently not the degranulation of prestimulated polymorphonuclear leukocytes. At higher concentrations of AAD, both respiratory burst and degranulation are inhibited, however. These effects can also be shown in complete blood samples." @default.
• W2029071731 created "2016-06-24" @default.
• W2029071731 creator A5017382735 @default.
• W2029071731 creator A5066693776 @default.
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• W2029071731 date "1998-07-01" @default.
• W2029071731 modified "2023-09-23" @default.
• W2029071731 title "Modulation of the Production of Reactive Oxygen Species by Pre-Activated Neutrophils by Aminoadamantane Derivatives" @default.
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• W2029071731 doi "https://doi.org/10.1016/s0006-2952(98)00024-0" @default.
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• W2029071731 hasPublicationYear "1998" @default.
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