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- W2029076722 abstract "Since it has been reported that dynorphin (1–13) enhances the analgetic effects of morphine in mice tolerant either to morphine or β-endorphin and modulates opioid agonist binding in the tolerant state, experiments were initiated to determine whether comparable phenomenon could be obtained in vitro with dynorphin-(1–13) on the isolated longitudinal muscle of the guinea pig ileum. In the guinea pig ileum rendered tolerant to morphine dynorphin-(1–13) was found to cause a dose-dependent restoration in sensitivity to the inhibitory action of morphine. This phenomenon appeared specific for dynorphin-(1–13) since [Leu 5 ]enkephalin, β-endorphin, and ethylketocyclazocine did not change significantly the IC 50 of morphine in the tolerant preparation. Furthermore, dynorphin-(1–13) attenuated the contraction elicited by naloxone in the morphine tolerant-dependent tissue. It is concluded, that dynorphin-(1–13) restores sensitivity to morphine in the tolerant-dependent state by a modulatory effect probably on the μ receptor that is distinct from its κ action." @default.
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- W2029076722 date "1984-07-01" @default.
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- W2029076722 title "Dynorphin-(1–13) restores the potency of morphine on the tolerant guinea pig ileum" @default.
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- W2029076722 doi "https://doi.org/10.1016/0014-2999(84)90568-5" @default.
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