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• W2029077961 endingPage "1039" @default.
• W2029077961 startingPage "1034" @default.
• W2029077961 abstract "Abstract: Treatment of PC12 cells with nerve growth factor (NGF), epidermal growth factor (EGF), or agents that raise intracellular cyclic AMP (cAMP) levels (e.g., forskolin) reduces the activity of calmodulin-dependent protein kinase III (CaM-PK III) over a period of 8 h. The mechanism of this effect of NGF has now been examined in more detail, making use of a mutant PC12 cell line (A126-1B2) that is deficient in cAMP-dependent protein kinase activity. Control experiments showed that A 126-1B2 cells retain other NGF-mediated responses (e.g., the induction of ornithine decarboxylase, a cAMP-independent event) and contain a complement of CaM-PK III and its substrate, elongation factor-2, comparable to that of wild-type cells. The ability of NGF or forskolin, but not of EGF, to down-regulate CaM-PK III was markedly attenuated in A 126-1B2 compared to wildtype cells. Treatment of wild-type cells with the cAMP phosphodiesterase inhibitor, isobutylmethylxanthine, enhanced the effects of NGF, but not of EGF. The possibility that NGF led to a stimulation of cAMP-dependent protein kinase activity in wild-type cells was assessed by measurement of the “activation ratio’(-cAMP/+cAMP) of this enzyme before and at various times after NGF addition. A small, but significant, increase in the activation ratio from 0.3 to 0.48 was observed, reaching a peak 5 min after NGF treatment. EGF had no effect on the activation ratio in wild-type cells. These experiments support the hypothesis that NGF, but not EGF, achieves its effects on CaM-PK III by activation of a cAMP-dependent protein kinase and suggest that other actions of NGF may be mediated by the same mechanism." @default.
• W2029077961 created "2016-06-24" @default.
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• W2029077961 date "1990-03-01" @default.
• W2029077961 modified "2023-09-27" @default.
• W2029077961 title "Nerve Growth Factor-Induced Down-Regulation of Calmodulin-Dependent Protein Kinase III in PC12 Cells Involves Cyclic AMP-Dependent Protein Kinase" @default.
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• W2029077961 doi "https://doi.org/10.1111/j.1471-4159.1990.tb02354.x" @default.
• W2029077961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1689374" @default.
• W2029077961 hasPublicationYear "1990" @default.
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